Clinical implications and prognostic significance of thrombocytopenia in Tunisian patients with systemic lupus erythematosus

Lupus
M JallouliZ Bahloul

Abstract

The objective of this study was to determine the role of thrombocytopenia in terms of disease manifestations, disease activity and prognostic impact in a cohort of Tunisian systemic lupus erythematosus (SLE) patients. The charts of 182 SLE patients diagnosed between 1996 and 2009 were retrospectively reviewed. The clinical manifestations, immunological profiles, disease activity, SLE relapses and survival rate at the time of follow-up were recorded. Thrombocytopenia (<100,000/mm(3)) and severe thrombocytopenia (<20,000/mm(3)) was observed in 19.2% and 4.4%, respectively. Hemorrhagic manifestations were observed in 11 patients (31.4%). Thrombocytopenia was significantly associated with splenomegaly, renal disorders, neurologic manifestations, arterial thrombosis, leucopenia, low C3 level at SLE diagnosis, SLE relapses and infectious complications. Using multivariate logistic regression, thrombocytopenia was independently associated with splenomegaly (odds ratio [OR] = 9.36, p = 0.001), neurologic manifestations (OR = 4.6, p = 0.006) and renal disease (OR = 4.15, p = 0.02). By multivariable Cox proportional hazard regression analyses, thrombocytopenia was associated with the occurrence of mortality after adjusting for variables k...Continue Reading

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Citations

Sep 17, 2013·Dental Clinics of North America·Giulio Fortuna, Michael T Brennan
Nov 4, 2015·Rheumatology International·Chao-Yu HsuChia-Hung Kao
Sep 4, 2016·Platelets·Sahar Mahfouz Abdel GalilWaleed Hussain
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Nov 4, 2020·La Revue de médecine interne·M MichelL Terriou

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
bone marrow aspiration

Software Mentioned

SPSS
PC

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