Clinical implications in laboratory parameter values in acute Kawasaki disease for early diagnosis and proper treatment

Korean journal of pediatrics
Yu-Mi SeoKyung-Yil Lee

Abstract

This study aimed to analyse laboratory values according to fever duration, and evaluate the relationship across these values during the acute phase of Kawasaki disease (KD) to aid in the early diagnosis for early-presenting KD and incomplete KD patients. Clinical and laboratory data of patients with KD (n=615) were evaluated according to duration of fever at presentation, and were compared between patients with and without coronary artery lesions (CALs). For evaluation of the relationships across laboratory indices, patients with a fever duration of 5 days or 6 days were used (n=204). The mean fever duration was 6.6±2.3 days, and the proportions of patients with CALs was 19.3% (n=114). C-reactive proteins (CRPs) and neutrophil differential values were highest and hemoglobin, albumin, and lymphocyte differential values were lowest in the 6-day group. Patients with CALs had longer total fever duration, higher CRP and neutrophil differential values and lower hemoglobin and albumin values compared to patients without CALs. CRP, albumin, neutrophil differential, and hemoglobin values at the peak inflammation stage of KD showed positive or negative correlations each other. The severity of systemic inflammation in KD was reflected in ...Continue Reading

References

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Citations

Oct 22, 2018·Clinical Rheumatology·Marco Antonio Yamazaki-NakashimadaHiromichi Hamada
Apr 20, 2019·Korean journal of pediatrics·Min Seob Song
Feb 13, 2020·Frontiers in Pediatrics·Seigo OkadaYuichi Ishikawa
Apr 23, 2020·Frontiers in Pediatrics·Kyung-Yil LeeMiika Arvonen

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