Clinical implications of AEG-1 in liver metastasis of colorectal cancer.

Medical Oncology
Tao JiangDaxun Piao

Abstract

The aim of the study was to investigate the role of AEG-1 in colorectal cancer and the relationship between AEG-1 protein expression and pathological characteristics and prognosis in colorectal cancer. The AEG-1 mRNA and protein expression level between the tumor cells from the cases with liver metastasis and those from the ones without live metastasis were detected by RT-PCR and immunohistochemistry staining. The relationship between AEG-1 and clinicopathological parameters of colorectal cancer was determined. AEG-1 expressed positively in 218 (41.92%) of the 520 cases examined. It showed that both mRNA and protein level AEG-1 were over-expressed in the cases with liver metastasis compared with those without liver metastasis (P=0.01). After immunohistochemistry analysis, the expression of AEG-1 protein was related to age, Duke's stage and distant metastasis (P=0.001, 0.001 and 0.016, respectively). After survival analysis, the cases with highly expressed AEG-1 protein attained a significantly poorer postoperative disease-specific survival than those with none/low-expressed AEG-1 protein (P=0.001). In the Cox regression test, histological grade, Duke's stage and AEG-1 were detected as the independent prognostic factors (P=0.035...Continue Reading

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Citations

Jun 21, 2014·Clinical & Experimental Metastasis·Sandra CasimiroLuis Costa
Mar 18, 2016·Scientific Reports·Sebastian GnosaXiao-Feng Sun
Apr 20, 2016·Progress in Neurobiology·Neha Vartak-SharmaAnuja Ghorpade
Feb 27, 2018·Technology in Cancer Research & Treatment·Huifang JinXianping Lv
Feb 20, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Enlin SongXiaoliang Xiong
Jul 11, 2014·Oncology Letters·Yong Huang, LE-Ping Li
Jan 10, 2018·Journal of Biochemical and Molecular Toxicology·Xiaoli SunXinwu Zhang
Apr 19, 2021·Computational Biology and Chemistry·Sushmitha SriramuluSurajit Pathak
May 15, 2021·OncoTargets and Therapy·Wubin ZhengWeiwei Tang
Sep 10, 2015·Oncology Research·Cong LiJiasheng Zheng

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