PMID: 7543218Jan 1, 1995Paper

Clinical implications of clozapine discontinuation: report of an NIMH workshop

Schizophrenia Bulletin
D ShoreJeffrey A Lieberman

Abstract

In September 1994, the National Institute of Mental Health convened a group of scientists to discuss the clinical effects of rapid clozapine discontinuation, especially in light of the introduction of risperidone for the treatment of schizophrenia. Despite concern over recent reports of clinical deterioration (psychotic exacerbations, somatic withdrawal symptoms, and extrapyramidal side effects) in a few patients abruptly discontinued from clozapine, there is currently insufficient information to determine the magnitude of the problems associated with clozapine withdrawal. However, clinicians are reminded that the withdrawal schedule for clozapine indicates a gradual tapering schedule (unless the patient is experiencing severe side effects); that switching patients from clozapine to risperidone does not mean that such tapering is unnecessary; and that the use of risperidone may not produce all of the same effects as clozapine in some treatment-refractory patients.

Citations

Dec 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Theresa A ZesiewiczRobert A Hauser
Aug 17, 1999·European Journal of Pharmacology·M L Wadenberg, P Seeman
Mar 26, 2002·Clinical Therapeutics·Andrew J CutlerJohn A Tumas
Feb 19, 1998·Schizophrenia Research·J L WaddingtonE O'Callaghan
Dec 17, 2004·Clinical Neuropharmacology·Andrew Wei-Chiang YehWei-Hsi Chen
Sep 26, 2002·Psychosomatics·Shishuka MalhotraRukhsana Iqbal
Jul 5, 2008·Clinical Drug Investigation·Luca PaniKöksal Alptekin
Jan 7, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·B GrassiS Scarone
Jan 28, 1998·Clinical Therapeutics·C Langley-Hawthorne
Aug 31, 2002·Current Medical Research and Opinion·T BurnsK Demyttenaere
Dec 1, 2004·Acta Neuropsychiatrica·Pierre ChueLili Kopala
Feb 5, 2011·Journal of Psychopharmacology·Thomas R E Barnes, UNKNOWN Schizophrenia Consensus Group of British Association for Psychopharmacology
Nov 4, 2011·Journal of Pharmacy Practice·James J GuggerCandace Smith
Nov 12, 2005·Journal of Clinical Psychopharmacology·Gary RemingtonShitij Kapur
Dec 18, 2001·Biological Psychiatry·R R Conley, D L Kelly

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