Clinical implications of cytogenetic abnormalities in melanoma

The Surgical Clinics of North America
M A NelsonR Taetle

Abstract

Unlike leukemia, in which specific reciprocal translocations are frequently observed, melanomas involve complex recurring chromosome anomalies. Analysis of the constituted genome of melanoma patients should identify cancer susceptibility genes and at-risk individuals in families with a history of melanoma. The first of these genes to be cloned is the cell cycle regulatory protein inhibitor--the p16 gene-- and a second gene locus for melanoma predisposition has been linked to the chromosome 1p36 band region. Detection of the most common somatic genetic alterations in melanoma enhances our understanding of molecular mechanisms of melanoma development and may lead to genetic markers in melanoma. Some alterations may be used to identify interesting subpopulations. Others may be of prognostic value when they are considered in tandem with clinical data.

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Citations

Apr 18, 2003·Cancer Genetics and Cytogenetics·Michal LotemDvorah Abeliovich
Apr 4, 2000·Oral Oncology·M J Hicks, C M Flaitz
Mar 26, 2003·The American Journal of Pathology·Jennifer Walker-DanielsMichael S Kinch
Mar 31, 2009·Critical Reviews in Oncology/hematology·Gabriela GremelWilliam M Gallagher
Jan 20, 2005·Gene·Amber KahleMark A Nelson
Mar 1, 2005·International Journal of Surgical Pathology·Michael W BeatyMaria J Merino
Jul 2, 1999·British Journal of Cancer·J A Newton BishopD T Bishop
Mar 10, 2001·Journal of Chemotherapy·F F Fagnoni, G Robustelli della Cuna

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