Clinical Implications of Diffuse Excessive High Signal Intensity (DEHSI) on Neonatal MRI in School Age Children Born Extremely Preterm

PloS One
Lina BroströmUlrika Adén

Abstract

Magnetic resonance imaging (MRI) of the brain carried out during the neonatal period shows that 55-80% of extremely preterm infants display white matter diffuse excessive high signal intensity (DEHSI). Our aim was to study differences in developmental outcome at the age of 6.5 years in children born extremely preterm with and without DEHSI. This was a prospective cohort study of 83 children who were born in Stockholm, Sweden, between 2004 and 2007, born at gestational age of < 27 weeks + 0 days and who underwent an MRI scan of their brain at term equivalent age. The outcome measures at 6.5 years included testing 66 children with the modified Touwen neurology examination, the Movement Assessment Battery for Children 2, the Wechsler Intelligence Scale for Children-Fourth Edition, Beery Visual-motor Integration test-Sixth Edition, and the Strengths and Difficulties Questionnaire. Group-wise comparisons were done between children with and without DEHSI using Student t-test, Mann Whitney U test, Chi square test and regression analysis. DEHSI was detected in 39 (59%) of the 66 children who were assessed at 6.5 years. The presence of DEHSI was not associated with mild neurological dysfunction, scores on M-ABC assessment, cognition, vi...Continue Reading

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Citations

Aug 24, 2017·Child Development·Mariagrazia BenassiKerstin Hellgren
Oct 19, 2019·AJNR. American Journal of Neuroradiology·S L MerharB Kline-Fath
May 27, 2020·Archives of Disease in Childhood. Fetal and Neonatal Edition·Chandra Prakash RathSanjay Patole
Dec 2, 2020·The Journal of Pediatrics·Nehal A ParikhUNKNOWN Cincinnati Infant Neurodevelopment Early Prediction Study (CINEPS) Investigators
Mar 19, 2021·Brain : a Journal of Neurology·Michael EyreA David Edwards
Jun 28, 2018·Pediatrics·Susan R HintzUNKNOWN SUPPORT study group of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research

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