Clinical implications of enzyme induction and enzyme inhibition

Clinical Pharmacokinetics
B K Park, A M Breckenridge

Abstract

The pharmacological effect of a drug is partly dependent upon its concentration at its site of action, which in turn is partly dependent upon its rate of elimination. The rate of elimination of many lipophilic drugs is governed by the activity of the hepatic microsomal mixed-function oxidases. Consequently any alteration in the activity of these enzymes may result in a modification of drug action. A wide range of chemically unrelated substances may stimulate the activity of the mixed-function oxidases by enzyme induction. The drugs most frequently encountered as enzyme-inducing agents in man are barbiturates, rifampicin and phenytoin. Enhancement of drug metabolism by ethanol, tobacco smoking and diet may also involve enzyme induction. Enzyme induction is normally associated with a reduction in the drug efficacy but may also alter the toxicity of certain substances. Enzyme induction has been assessed in man by measuring changes in the pharmacokinetics of a marker drug, or changes in the disposition of endogenous compounds such as gamma-glutamyltranspeptidase, D-glucaric acid and 6beta-hydroxycortisol. The therapeutic problems associated with enzyme inhibition have received much less attention than those associated with enzyme i...Continue Reading

Citations

Nov 1, 1993·Journal of Clinical Pharmacology·M PaoliniG Cantelli-Forti
Feb 1, 1994·Journal of Clinical Pharmacology·I H BenedekH J Pieniaszek
Jan 1, 1984·European Journal of Clinical Pharmacology·G G ThompsonM J Brodie
Jan 1, 1985·European Journal of Clinical Pharmacology·J PosnerP D Whiteman
Jan 1, 1985·European Journal of Clinical Pharmacology·H P HoenschE E Ohnhaus
Jan 1, 1982·European Journal of Clinical Pharmacology·P J PentikäinenH A Hiltunen
Jan 1, 1989·European Journal of Clinical Pharmacology·H WietholtzS Matern
Jan 1, 1989·European Journal of Clinical Pharmacology·E E OhnhausB K Park
Jan 1, 1988·European Journal of Clinical Pharmacology·M SanoM Goto
Apr 1, 1985·Biulleten' eksperimental'noĭ biologii i meditsiny·A S LoginovE A Bendikov
Feb 1, 1983·Biulleten' eksperimental'noĭ biologii i meditsiny·B N MatiushinT V Nilova
Oct 1, 1986·Digestive Diseases and Sciences·E B KeeffeJ D Gabourel
Dec 1, 1991·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·M Orme, D J Back
Dec 13, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·D W AchesonJ M Braganza
Jan 1, 1987·Pharmacology & Therapeutics·A P GeubelC Dive
Jan 1, 1987·Pharmacology & Therapeutics·G C Farrell
Jan 1, 1988·Pharmacology & Therapeutics·P H Beaune, F P Guengerich
Jan 1, 1990·Pharmacology & Therapeutics·M Barry, J Feely
Jan 1, 1990·Pharmacology & Therapeutics·A B Okey
Jan 1, 1995·Pharmacology & Therapeutics·B Rogvi-Hansen, L Gram
Apr 1, 1986·Clinical Biochemistry·A B OkeyM S Denison
Oct 24, 1987·Lancet·S J WilliamsG C Farrell
Jul 30, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jochen G W TheisJohn Ascher
Mar 24, 1983·The New England Journal of Medicine
Nov 2, 2001·AIDS Patient Care and STDs·J R ToddJ W King
Jul 1, 1990·British Journal of Clinical Pharmacology·J M CastelR Latini
Dec 1, 1990·British Journal of Clinical Pharmacology·P CrawfordM Orme
Dec 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·D M BohlenS L Burrows
Jul 1, 1992·Antimicrobial Agents and Chemotherapy·S M BorcherdingR L Lalonde
Jul 24, 1982·British Medical Journal·V C Valsalan, G L Cooper
Mar 19, 1988·British Medical Journal·M J Brodie, J Feely
Jan 1, 1990·British Journal of Industrial Medicine·A Moretto, M Lotti
Jan 26, 2002·Journal of Clinical Pharmacology·Norio Yasui-Furukori, Tomonori Tateishi
Nov 1, 1994·Environmental Health Perspectives·M Strolin Benedetti, P Dostert
Jun 15, 1999·Drug Metabolism and Drug Interactions·J R Schein
Jun 9, 2004·Toxicological Reviews·Florian EyerPeter Eyer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.