Clinical implications of growth factors in flexor tendon wound healing

The Journal of Hand Surgery
Charles Hsu, James Chang

Abstract

Recent research has focused on the role of growth factors in flexor tendon wound healing. These basic science reports have described the identification and quantification of various growth factors in in vitro and in vivo models. Although these reports have begun to piece together the cascade of events involved in flexor tendon wound healing, the clinical relevance for the practicing hand surgeon is unclear. Growth factors are cell-secreted proteins that regulate cellular functions. These growth factors are involved in cell differentiation and growth, including the normal processes of development and tissue repair. Several growth factors recently have been identified as playing roles in tendon healing including vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF), and transforming growth factor beta (TGF-beta). In addition, the transcription factor NF-kappaB has been implicated in the signaling pathways of these growth factors. The purpose of this article is to describe what is known about the molecular basis of flexor tendon wound healing, to review the most commonly studied growth factors, and to summarize likely clinical appli...Continue Reading

References

May 1, 1976·The Journal of Bone and Joint Surgery. British Volume·P Matthews, H Richards
May 1, 1977·The Journal of Bone and Joint Surgery. British Volume·G EskelandJ Teigland
Nov 1, 1992·Endocrine Reviews·L C Giudice
Mar 1, 1992·British Journal of Cancer·V M Macaulay
Sep 30, 1992·Biochemical and Biophysical Research Communications·B I TermanP Böhlen
Jul 1, 1992·The Journal of Clinical Investigation·W A Border, E Ruoslahti
Nov 1, 1991·Journal of Cellular Biochemistry·N FerraraD W Leung
Sep 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J E Russell, P R Manske
Jan 1, 1991·Annual Review of Medicine·T F DeuelA F Pierce
Apr 1, 1991·Journal of Cellular Biochemistry·G F PierceA Thomason
Apr 1, 1991·Journal of Cellular Biochemistry
Jul 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S O AbrahamssonL S Lohmander
Jul 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S O AbrahamssonL S Lohmander
Jan 23, 1987·Science·J Folkman, M Klagsbrun
Jan 1, 1987·Nouvelle Revue Française D'hématologie·A Camez, G Tobelem
Jul 1, 1987·Molecular Endocrinology·L J MurphyH G Friesen
Dec 29, 1989·Biochemical and Biophysical Research Communications·E TischerJ A Abraham
Aug 1, 1989·The Journal of Clinical Investigation·S E LynchH N Antoniades
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G F PierceT F Deuel
Jan 1, 1988·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A J BanesL Dahners
Jan 1, 1988·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·H A HanssonA Skottner
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S E LynchH N Antoniades
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R RossL Harker
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C A FrolikM B Sporn

❮ Previous
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Citations

Mar 30, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yong FengJing Li
Jun 7, 2005·Cytokine & Growth Factor Reviews·Howard Seeherman, John M Wozney
Jan 30, 2010·Injury·L ObertP Garbuio
Jan 9, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Patrick BasileHani A Awad
Dec 8, 2011·Tissue Engineering. Part B, Reviews·Christopher K HeeJeffrey O Hollinger
Jul 7, 2011·British Medical Bulletin·Tomoya Sakabe, Takao Sakai
Jul 11, 2013·PloS One·Jianying ZhangJames H-C Wang
May 3, 2011·American Journal of Veterinary Research·Lance C VisserKeri L Gardner
Aug 11, 2010·Indian Journal of Orthopaedics·Narender SainiSp Gupta
Jul 13, 2012·International Journal of Shoulder Surgery·M SchaerM A Zumstein
May 20, 2014·Hand : Official Journal of the American Association for Hand Surgery·K M KollitzJ I Huang
Jun 7, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Min WangWei Xiao
Aug 12, 2014·Foot and Ankle Surgery : Official Journal of the European Society of Foot and Ankle Surgeons·Matteo GuelfiVincenzo Salini
Dec 2, 2014·The Orthopedic Clinics of North America·Kevin F LutskyJonas L Matzon
Dec 30, 2014·Advanced Drug Delivery Reviews·Diana GasparDimitrios Zeugolis
Jul 10, 2012·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Cagri A UysalHiroshi Mizuno
Apr 24, 2012·Journal of Shoulder and Elbow Surgery·Sven HoppeMatthias A Zumstein
Apr 2, 2011·Journal of Shoulder and Elbow Surgery·Stephan PaulyBritt Wildemann
Mar 29, 2011·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Dimitris N LyrasGeorge Agrogiannis
Mar 5, 2009·The Journal of Hand Surgery·B R KlassA O Grobbelaar
Mar 22, 2008·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Duretti FufaMartha M Murray
Nov 11, 2006·The Journal of Hand Surgery·Mohammad M Al-Qattan
May 13, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·May JacobsonMartha M Murray
Oct 19, 2010·The Journal of Hand Surgery·Yutaka MorizakiPeter C Amadio
May 23, 2006·The Journal of Hand Surgery·Deqing HuangA Bobby Chhabra
Aug 4, 2015·Foot and Ankle Surgery : Official Journal of the European Society of Foot and Ankle Surgeons·Matteo GuelfiVincenzo Salini
May 24, 2011·Current Biology : CB·Toru MaedaTakao Sakai
Nov 11, 2014·Journal of Tissue Engineering·Jasmine Oy HoVivek Mudera
Jul 9, 2011·The American Journal of Sports Medicine·Chris Hyunchul JoSue Shin
Aug 31, 2010·The American Journal of Sports Medicine·Jianying Zhang, James H-C Wang

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