Clinical Implications of Mutations in the PI3K Pathway in HER2+ Breast Cancer: Prognostic or Predictive?

Current Breast Cancer Reports
Ingrid A Mayer

Abstract

Recent advances in tumor genetics and drug development have led to the generation of a wealth of anti-cancer-targeted therapies. These drugs aim at targeting a particular vulnerability in the tumor generated in most cases as a result of dependence on an oncogene and/or loss of a tumor suppressor. Genes in the phosphoinositide 3-kinase (PI3K)/AKT pathway are the most frequently altered in human cancers. Aberrant activation of the PI3K/AKT pathway has been shown to confer resistance to HER2-targeted therapies. Several drugs targeting PI3K/ATK have been developed and are currently in clinical trials in different phases of clinical development, alone or in combination. The impact of mutations in the phosphoinositide 3-kinase (PI3K)/AKT pathway in HER2-amplified breast cancers will be the focus of this review.

References

May 10, 2006·Nature Clinical Practice. Oncology·Rita NahtaFrancisco J Esteva
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Laura M Bender, Rita Nahta
Feb 11, 2011·Cancer Biology & Therapy·Joan T Garrett, Carlos L Arteaga
Dec 14, 2011·The New England Journal of Medicine·José BaselgaUNKNOWN CLEOPATRA Study Group
Dec 17, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J D JensenM Ewertz
Jan 5, 2012·The Journal of Clinical Investigation·Kathryn M KinrossWayne A Phillips
Feb 15, 2012·Breast Cancer Research : BCR·Magdalena CizkovaIvan Bièche
Sep 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·John E BurkeRoger L Williams
Jun 7, 2013·Journal of the National Cancer Institute·Sherene LoiChristos Sotiriou
Aug 14, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ariella B HankerCarlos L Arteaga
Sep 10, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sibylle LoiblCarsten Denkert
Oct 22, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·José BaselgaSandra M Swain
Dec 24, 2014·Nature Reviews. Cancer·Lauren M ThorpeJean J Zhao
Jan 7, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Katherine L Pogue-GeileSoonmyung Paik
Jan 7, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ian J MajewskiJosé Baselga
Aug 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J D JensenM Ewertz

❮ Previous
Next ❯

Citations

Jan 17, 2019·Journal, Genetic Engineering & Biotechnology· Desriani, Fuad Al-Ahwani

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Related Papers

Annual Review of Medicine
Ingrid A Mayer, Carlos L Arteaga
Annals of the New York Academy of Sciences
Micka C Bertucci, Christina A Mitchell
Journal of Mammary Gland Biology and Neoplasia
Justin Cidado, Ben Ho Park
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Sarat ChandarlapatyTari A King
World Journal of Clinical Cases
Tasuku Matsuoka, Masakazu Yashiro
© 2022 Meta ULC. All rights reserved