Clinical implications of N-cadherin expression in gastric cancer

Pathology International
Takahito KamikiharaShoji Natsugoe

Abstract

Neo-expression of N-cadherin in cancer cells is regarded as a significant event in tumor progression via epithelial-mesenchymal transition (EMT). No reports have detailed the clinical impact of N-cadherin expression in gastric cancer. We retrospectively examined the co-expression of N-cadherin and E-cadherin in human gastric carcinoma and analyzed the clinicopathological significance of N-cadherin expression. One hundred and forty-six gastric cancer patients who received curative gastrectomy were enrolled. E-cadherin and N-cadherin immunoreactivity in cancer tissue was evaluated by the avidin-biotin-peroxidase complex technique. The correlation between N-cadherin and E-cadherin expression and clinicopathological parameters were analyzed. N-cadherin-positive and -negative expression were found in 31 and 115 patients, respectively. N-cadherin expression positively correlated with hematogenous recurrence (P < 0.01) and negatively correlated with patients' postoperative outcomes (P < 0.05). Moreover, only in the E-cadherin-preserved group was prognostic significance found according to N-cadherin expression (P < 0.01). We could not show a significant relationship between N-cadherin expression and EMT in gastric cancer. However, neo ...Continue Reading

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Citations

Oct 2, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhan-shan WangJi-kun Li
Feb 6, 2018·Medical Oncology·Yoichi YamasakiShoji Natsugoe
Mar 2, 2018·Medical Oncology·Dorota Ciołczyk-Wierzbicka, Piotr Laidler
Jul 23, 2015·Applied Immunohistochemistry & Molecular Morphology : AIMM·Shahroo Etemad-Moghadam, Mojgan Alaeddini
Mar 2, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Keishi OkuboShoji Natsugoe
Jun 27, 2020·Cancer Cell International·Xiongdong ZhongNi Gu
Oct 28, 2019·Biochimica Et Biophysica Acta. Reviews on Cancer·Ke WangJi-Peng Li
May 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tiantian CaiXiaohui Zeng
Nov 14, 2019·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Tao Xiao, Zhigang Jie

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