PMID: 20626340Jul 16, 2010Paper

Clinical implications of non-invasive measurement of central aortic blood pressure

Current Vascular Pharmacology
Mariusz StepieńJacek Rysz

Abstract

Central arterial systolic blood pressure is a very important factor in the pathophysiology of cardiovascular diseases. Central arterial pressure is a better predictor of cardiovascular risk than peripheral brachial blood pressure. Measurement of central blood pressure is useful for a diagnosis of spurious systolic hypertension in young people. Antihypertensive drugs have a different impact on central blood pressure, for example angiotensin converting enzyme inhibitors, antagonists of angiotensin II receptors, calcium channel blockers more effectively lower central blood pressure than betablockers, despite all of those drugs (including beta-blockers) having a similar impact on peripheral pressure. This mechanism may be responsible for the beneficial effect of some antihypertensive drugs on cardiovascular end points observed in clinical trials, despite a low peripheral hypotensive effect. However, further clinical trials are required to provide more evidence for the prognostic and therapeutic implications of the measurement of central blood pressure before adopting its routine application in clinical practice.

Citations

Oct 12, 2012·Current Hypertension Reports·Maciej Banach, Wilbert S Aronow
Apr 9, 2011·Current Cardiovascular Risk Reports·Agata Bielecka-DabrowaMaciej Banach
Apr 27, 2011·Expert Opinion on Pharmacotherapy·Maciej BanachJacek Rysz
Oct 28, 2010·Expert Opinion on Pharmacotherapy·Maciej Banach, Jacek Rysz

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