Clinical implications of pathological features of primary membranous nephropathy

BMC Nephrology
Xiao-Dan ZhangMing-Hui Zhao

Abstract

The clinical outcome varies considerably in primary membranous nephropathy (pMN). Risk factors for kidney prognosis include ageing, male gender, persistent heavy proteinuria, decreased eGFR at presentation, persistent elevation of anti-PLA2R antibodies, no remission, and so on. It was controversial whether the histopathological features of pMN could predict treatment response and kidney outcome. A retrospective study was conducted in 371 patients with biopsy-proven pMN. Pathological parameters included immunofluorescence staining, membranous Churg's stages, sclerosis, crescent, focal segmental sclerosis lesion, chronic and acute tubulointerstitial injury. The fluorescence intensity was determined: 0, negative; 1, weak; 2, moderate; 3, strong; 4, glaring. Chronic tubulointerstitial injury was graded by the involved area: 0, 0-5%; 1, 6-25%; 2, 26-50%; 3, > 50%. We found that patients with higher intensity of C3 staining, advanced membranous stage, and more severe chronic tubulointerstitial injury presented with higher positivity rate of anti-PLA2R antibodies, higher levels of urinary protein excretion and serum creatinine, and lower level of serum albumin. Univariate Cox regression analysis showed that severe (grade = 3) chronic ...Continue Reading

References

Apr 1, 1992·Kidney International·P E BrenchleyN P Mallick
Feb 1, 1992·Kidney International·S Wakai, A B Magil
Jan 5, 1989·The New England Journal of Medicine·C PonticelliB Redaelli
Apr 12, 1984·The New England Journal of Medicine·C PonticelliT Volpini
Jul 8, 1993·The New England Journal of Medicine·A SchieppatiG Remuzzi
Jan 15, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L J ReichertJ F Wetzels
Aug 5, 1999·Kidney International·B E Marx, M Marx
Apr 11, 2000·Current Opinion in Nephrology and Hypertension·G J Becker, T D Hewitson
Feb 7, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Q WuK Kurokawa
Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Alexandre DumoulinAlain Meyrier
Dec 17, 2003·Kidney International·Keiichi YoshimotoHiroshi Kida
Apr 17, 2004·Kidney International·Hideo ShiikiUNKNOWN Research Group on Progressive Renal Diseases in Japan
Nov 26, 2004·Journal of the American Society of Nephrology : JASN·Amanda J W BrantenJack F Wetzels
Mar 31, 2006·Kidney International·S TroyanovD C Cattran
Sep 22, 2006·Journal of the American Society of Nephrology : JASN·Ying-Chun MaHai-Yan Wang
Jul 3, 2009·The New England Journal of Medicine·Laurence H BeckDavid J Salant
Apr 9, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Julia M HofstraDavid J Salant
Jul 26, 2011·Journal of the American Society of Nephrology : JASN·Laurence H BeckDavid J Salant
May 19, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Jan A J G van den BrandJack F M Wetzels
Mar 13, 2014·Journal of the American Society of Nephrology : JASN·Elion HoxhaRolf A K Stahl
Mar 26, 2015·Journal of the American Society of Nephrology : JASN·Piero RuggenentiGiuseppe Remuzzi
Nov 1, 2016·Journal of the American Society of Nephrology : JASN·Daniel C CattranUNKNOWN Toronto Glomerulonephritis Registry group
Aug 13, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Jia WangMing-Hui Zhao

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Methods Mentioned

BETA
electron microscopy
biopsy
ELISA

Software Mentioned

SPSS

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