Clinical implications of pharmacogenetic and microarray testing for advanced practice nurses

Journal of the American Association of Nurse Practitioners
Kathleen S Brennan

Abstract

The rapidly changing field of pharmacogenetics requires that advanced practice providers have a fundamental foundation in genetics and genetic testing on which new knowledge can be built. Testing for allelic variation in the well-researched Cytochrome P450 pathways and other pathways of drug metabolism is done through microarray testing. Understanding the process microarray testing provides a framework for understanding pharmacogenetic testing. Genetic, pharmacogenetic, and biotechnical literature is reviewed to explain the genetics and biotechnology behind testing for allelic variation. Clinical examples of applied pharmacogenetic testing in cardiology and psychiatry are provided from the nursing literature. The advent and practical application of inexpensive and available testing aimed to identify genetic variations in individual patient metabolism of common and critical medications, necessitates that advanced practice registered nurses (APRNs) have a deeper understanding of the biotechnology involved in pharmacogenetic and pharmacogenomics testing. Providers with a working knowledge of the microarray testing method will have a framework for understanding which patients to test, what tests to order, and how to interpret the r...Continue Reading

References

Sep 14, 2004·Clinical Nurse Specialist CNS·Theresa A Beery, Marcia J Hern
Apr 22, 2008·Critical Care Nursing Clinics of North America·Cynthia A Prows, Theresa A Beery
Aug 7, 2009·American Journal of Pharmaceutical Education·Evgeny Krynetskiy, Ina Lee Calligaro
Oct 13, 2009·Clinical Pharmacokinetics·Shu-Feng Zhou
Nov 12, 2009·Clinical Pharmacokinetics·Shu-Feng Zhou
Mar 12, 2010·American Journal of Pharmaceutical Education·Tracy Zembles
Apr 27, 2011·American Journal of Pharmaceutical Education·John A SpringerJon E Sprague
Jun 21, 2011·Frontiers in Pharmacology·Concetta CrisafulliAlessandro Serretti
Sep 9, 2011·Journal of the American Academy of Nurse Practitioners·Joan LandinoGualberto Ruaño
Aug 30, 2012·Clinical Pharmacology and Therapeutics·P H O'DonnellM J Ratain
Apr 24, 2013·Journal of Child and Adolescent Psychiatric Nursing : Official Publication of the Association of Child and Adolescent Psychiatric Nurses, Inc·Rose Marie Turner
Dec 4, 2013·The Nursing Clinics of North America·Stephen D Krau
Dec 4, 2013·The Nursing Clinics of North America·Stephen D Krau
May 28, 2014·Nursing Outlook·Mitchell R KniselyDiane Von Ah

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Citations

Aug 20, 2020·Revista latino-americana de enfermagem·Jordana Carvalhaes de MoraesRiccardo Lacchini

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