Clinical implications of systemic inflammatory response syndrome following thoracic aortic stent-graft placement

Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists
Holger EggebrechtR Erbel

Abstract

To quantify inflammatory markers in a large cohort of patients undergoing thoracic endovascular aortic repair (TEVAR) and investigate if profound biomarker elevations may be predictors of postprocedural death. We analyzed data from 103 patients (70 men; mean age 64.5+/-11.2 years, range 22-83) undergoing TEVAR between July 1999 and December 2006. Baseline as well as at least 3 serial measurements of C-reactive protein (CRP), fibrinogen, white blood cell (WBC) count, and D-dimers were performed within the first 20 days after TEVAR. Compared with baseline, all inflammatory biomarker levels rose significantly. WBC peaked 2 days after the procedure, whereas CRP, fibrinogen, and D-dimers showed a sustained elevation up to 20 days after TEVAR. Inflammatory responses were more pronounced in patients with acute aortic pathology compared with chronic aortic diseases. There was evidence of greater increase in biomarkers with an increasing number of stent-grafts implanted. Kaplan-Meier analysis suggested that increasing maximum D-dimer values postoperatively were associated with decreased survival after TEVAR (p=0.036) in a subset of patients; however, multivariate analysis failed to identify postinterventional biomarker elevation as inde...Continue Reading

References

Oct 1, 1983·The Surgical Clinics of North America·A J Schneider
May 1, 1997·Journal of Endovascular Surgery : the Official Journal of the International Society for Endovascular Surgery·L Norgren, P Swartbol
May 20, 1999·The New England Journal of Medicine·C A NienaberA Pierangeli
Oct 14, 2000·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·J R BoyleM M Thompson
Jul 4, 2001·Journal of Vascular and Interventional Radiology : JVIR·N KatoK Takeda
Aug 21, 2001·European Heart Journal·R ErbelUNKNOWN Task Force on Aortic Dissection, European Society of Cardiology
May 7, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·K J SweeneyJ V Reynolds
Jan 28, 2005·European Heart Journal·Holger EggebrechtDietrich Baumgart
Oct 18, 2005·European Heart Journal·Holger EggebrechtRaimund Erbel
Feb 13, 2007·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·T J ParkinsonM G Wyatt

❮ Previous
Next ❯

Citations

Mar 1, 2009·Seminars in Interventional Radiology·Grace J Wang, Ronald M Fairman
May 21, 2014·The Annals of Thoracic Surgery·Philipp KahlertMarc Schlamann
Mar 13, 2014·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Jian-Cheng ZhuHui Xu
Dec 15, 2012·American Heart Journal·Toru SuzukiRyozo Nagai
Oct 22, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Riccardo GorlaRolf Alexander Jánosi
Oct 23, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Konstantinos G MoulakakisGeorge Geroulakos
Dec 23, 2008·Journal of Vascular Surgery·Marcelo FerreiraMarcelo Monteiro
Mar 27, 2015·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Konstantinos G MoulakakisChristos D Liapis
Jul 15, 2015·European Heart Journal. Acute Cardiovascular Care·Riccardo GorlaRolf Alexander Jánosi
Nov 7, 2017·European Heart Journal·Eduardo BossoneKim A Eagle
Sep 23, 2020·Current Problems in Cardiology·Eduardo BossoneArturo Evangelista
Nov 9, 2021·Aorta : Official Journal of the Aortic Institute at Yale-New Haven Hospital·Eduardo BossoneRaimund Erbel
Dec 29, 2021·Aorta : Official Journal of the Aortic Institute at Yale-New Haven Hospital·Eduardo BossoneRaimund Erbel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

© 2022 Meta ULC. All rights reserved