Clinical implications of the BRAF mutation in papillary thyroid carcinoma and chronic lymphocytic thyroiditis

Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale
Woon Won KimSung Kwon Bae

Abstract

The purpose of this study was to examine the possible prognostics and clinicopathologic characteristics underlying the BRAFV600E mutation and papillary thyroid carcinoma (PTC) coexisting or in absence of chronic lymphocytic thyroiditis (CLT). This study was conducted on 172 patients who had undergone total thyroidectomy or unilateral total thyroidectomy for PTC; the patients were then examined for the BRAFV600E mutation using specimens obtained after their surgery from January 2013 to August 2015. BRAF mutations were found in 130 of 172 patients (75.6%). CLT was present in 27.9% of patients (48/172). The incidence of the BRAFV600E mutation was significantly increased in the group with no CLT (P = 0.001). The findings of the multivariate analysis pertaining to the coexistence of CLT and PTC showed no significant correlation other than the BRAFV600E mutation. No significant difference was noted in the clinicopathologic factors between the two groups based on the coexistence of CLT in univariate and multivariate analyses. The BRAFV600E mutation is less frequent in PTC coexisting with CLT presumably because CLT and the BRAFV600E mutation operate independently in the formation and progression of thyroid cancer.

References

Feb 1, 1955·A.M.A. Archives of Surgery·M E DAILEYR SKAHEN
Jan 8, 2013·The Journal of Clinical Endocrinology and Metabolism·Bojana JankovicJerome M Hershman
Mar 19, 2013·Thyroid : Official Journal of the American Thyroid Association·Jae Yun LimJae Yong Cho
Apr 11, 2013·JAMA : the Journal of the American Medical Association·Mingzhao XingVlasta Sykorova
May 15, 2013·Lancet·Mingzhao XingMartin Schlumberger
Jan 7, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Xin LiuXiaodong Liu
Aug 8, 2014·Endocrine Journal·Yasuhiro ItoAkihiro Miya
Sep 3, 2014·World Journal of Surgical Oncology·Yi ZhangHao Chen

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Citations

Sep 28, 2018·The British Journal of Radiology·Partha S Choudhury, Manoj Gupta

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Methods Mentioned

BETA
PCR

Software Mentioned

SPSS

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