PMID: 9180060Apr 1, 1997Paper

Clinical implications of the "Multicenter Automatic Defibrillator Implantation Trial" (MADIT)

Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
S Nisam, P Adragão

Abstract

Efficacious therapy for chronic coronary patients, known to be at high risk of sudden arrhythmic death, has been a long-lasting challenge for cardiologists. The "Multicenter Automatic Defibrillator Implantation Trial" (MADIT) has demonstrated in a prospective, randomized trial that such patients achieve 54% better survival (p < or = 0.009) when treated with implantable defibrillators (ICDs) compared to conventional pharmaceutical therapy-primarily amiodarone. The identification of these patients is well-defined, and patients with previous myocardial infarction fitting the appropriate risk profile as defined by MADIT (ejection.fraction < or = 0.35), non-sustained ventricular tachycardia should seriously be considered for prophylactic ICD implantation.

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