Clinical importance of detecting exaggerated blood pressure response to exercise on antihypertensive therapy

Heart
Reiko MizunoMasaharu Yamazaki

Abstract

In patients with hypertension, regression of left ventricular hypertrophy (LVH) is associated with improved prognosis. Impact of exaggerated blood pressure response to exercise (Ex-BP) seen in patients with hypertension undergoing antihypertensive therapy on the regression of LVH has not been evaluated. This prospective study investigated the relationship between Ex-BP on antihypertensive therapy and the regression of LVH. We prospectively studied 124 never-treated patients with hypertension with LVH. After a pretreatment evaluation, antihypertensive treatment was started and exercise test was performed in all patients. Patients with Ex-BP were divided into the Ex-BP (+) group and those without were divided into the Ex-BP (-) group. Regression of LVH over the follow-up period was compared between the groups. The follow-up duration was approximately 12 months in both the groups. Mean values of blood pressure at rest during the follow-up period were similar between the groups. Reduction of LVH was seen in both the groups. The magnitude of reduction of LVH was significantly smaller in the Ex-BP (+) group compared with the Ex-BP (-) group. Regression of LVH was much frequently seen in the Ex-BP (+) group compared with the Ex-BP (-)...Continue Reading

References

Sep 17, 1982·Deutsche medizinische Wochenschrift·I W Franz, F W Lohmann
May 20, 1999·Journal of the American College of Cardiology·J G WarnerW C Little
Jul 25, 2000·Circulation·B H Lorell, B A Carabello
Aug 2, 2000·American Journal of Hypertension·M Esler
Oct 21, 2000·Hypertension·M J RomanR B Devereux
May 21, 2003·Journal of Human Hypertension·J SungK J Stewart
Nov 18, 2004·JAMA : the Journal of the American Medical Association·Peter M OkinUNKNOWN LIFE Study Investigators
Feb 21, 2006·Journal of the American College of Cardiology·Peter KokkinosSteve Singh
Sep 1, 2007·Journal of Hypertension·Giuseppe ManciaUNKNOWN ESH-ESC Task Force on the Management of Arterial Hypertension
Jul 19, 2008·Journal of the American College of Cardiology·Chi Young ShimNamsik Chung

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Citations

Jun 14, 2018·Hypertension·Benjamin ChantEmma C Hart
Jun 17, 2020·Clinical and Experimental Hypertension : CHE·Kadir Uğur MertBülent Görenek
Aug 11, 2020·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Quênia Janaína Tomaz de CastroAndrea Grabe-Guimarães
Sep 4, 2020·Current Hypertension Reports·Shelley E KeatingTom G Bailey

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