Clinical Importance of Myc Family Oncogene Aberrations in Epithelial Ovarian Cancer

JNCI Cancer Spectrum
MoonSun JungMichelle J Henderson

Abstract

The Myc oncogene family has been implicated in many human malignancies and is often associated with particularly aggressive disease, suggesting Myc as an attractive prognostic marker and therapeutic target. However, for epithelial ovarian cancer (EOC), there is little consensus on the incidence and clinical relevance of Myc aberrations. Here we comprehensively investigated alterations in gene copy number, expression, and activity for Myc and evaluated their clinical significance in EOC. To address inconsistencies in the literature regarding the definition of copy number variations, we developed a novel approach using quantitative polymerase chain reaction (qPCR) coupled with a statistical algorithm to estimate objective thresholds for detecting Myc gain/amplification in large cohorts of serous (n = 150) and endometrioid (n = 80) EOC. MYC, MYCN, and MYCL1 mRNA expression and Myc activity score for each case were examined by qPCR. Kaplan-Meier and Cox-regression analyses were conducted to assess clinical significance of Myc aberrations. Using a large panel of cancer cell lines (n = 34), we validated the statistical algorithm for determining clear thresholds for Myc gain/amplification. MYC was the most predominantly amplified of t...Continue Reading

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Citations

Nov 21, 2019·Proteomics. Clinical Applications·Shahzadi NoreenMuhammad Waheed Akhtar
Mar 14, 2021·Cell Chemical Biology·Dhanir TailorSanjay V Malhotra
Mar 16, 2021·Frontiers in Oncology·Jeyshka M Reyes-González, Pablo E Vivas-Mejía
Nov 9, 2020·Seminars in Cancer Biology·Alexandre André Balieiro Anastácio da Costa, Glauco Baiocchi

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Methods Mentioned

BETA
light microscopy

Software Mentioned

GraphPad Prism
SPSS

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