Clinical important dysregulation of long non-coding RNA CCHE1 and HULC in carcinogenesis of cervical cancer

Molecular Biology Reports
Neda Naghashi, Saeid Ghorbian

Abstract

Genetic analysis has revealed that the lncRNAs acted in the critical pathways including cell growth, cell differentiation, and tumorigenesis. The purpose of the present survey was to evaluate the lncRNA-CCHE1 and lncRNA-HULC expression variations in subjects with cervical malignancy. In our case-control analysis planned on 100 formalin-fixed paraffin-embedded (FFPE) samples comprising 50 paraffin blocks of cervical cancerous and 50 paraffin blocks of non-tumors samples. We have calculated the lncRNA-CCHE1 and lncRNA-HULC gene expression alterations using a quantitative RT-PCR approach. Our results declared that the lncRNA-CCHE1 expression was considerably raised in tumorous matched to the non-tumorous samples (P = 0.001). Moreover, the lncRNA-HULC expression was not considerably modified between tumorous samples matched to the non-tumorous samples (P = 0.060). In extension, lncRNA-CCHE1 expression variation was correlated with the histological type (P = 0.001), tumor size (P = 0.001) and FIGO stage (P = 0.001). Our data advised that the lncRNA-CCHE1 gene may influence cervical malignancy progression, held as a prognostic marker and useful curative target. However, the character of lncRNA-HULC in carcinogenesis of cervical malig...Continue Reading

References

May 16, 2009·European Journal of Gastroenterology & Hepatology·Imad J MatoukMutaz Akkawi
Mar 17, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Subramanyam DasariLokanatha Valluru
Apr 15, 2015·Journal of the National Comprehensive Cancer Network : JNCCN·Wui-Jin KohJillian L Scavone
Apr 30, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Meng YangGe Lou
Dec 31, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Li PengGuan-Cheng Li
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wei Peng, Hong Fan
Aug 19, 2018·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Tao ZhangMing-Jie Wang
Nov 25, 2018·Experimental and Molecular Pathology·Hamid Aalijahan, Saeid Ghorbian
Dec 30, 2018·International Journal of Biological Macromolecules·Haomiao FengYuanyuan Zhang

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Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

Oligo Analyzer
SPSS

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