Clinical indicators of genetic susceptibility to epilepsy

Epilepsia
Ruth OttmanM Susser

Abstract

We evaluated clinical indicators of genetic susceptibility to epilepsy in the families of 1,957 adults with epilepsy (probands) ascertained from voluntary organizations. Very few of the probands in this series had idiopathic epilepsy syndromes. Among relatives of probands with postnatal CNS insults, risks of epilepsy were no higher than in the general population. Risk was increased in relatives of probands without identified CNS insults (i.e., those with idiopathic/cryptogenic epilepsy) or with neurological deficit presumed present at birth, compared with relatives of probands with postnatal CNS insults. Among relatives of probands with idiopathic/cryptogenic epilepsy, risks were higher in parents and siblings, but not in offspring, of probands with generalized onset as compared with partial onset seizures. Risks in offspring were higher if the probands had onset of idiopathic/cryptogenic epilepsy before age 10 as compared with age > or = 10 years, but risks in parents and siblings were not associated with the probands's age at onset. These results suggest that genetic susceptibility increases risk of some forms of cryptogenic epilepsy and of epilepsy associated with neurological deficit presumed present at birth, but not of po...Continue Reading

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Citations

Mar 31, 1998·Archives of Neurology·R OttmanN Risch
Apr 1, 1996·Annals of Neurology·R OttmanM Susser
Oct 29, 2004·Current Neurology and Neuroscience Reports·Panayiotis N Varelas, Marek A Mirski
Feb 22, 2001·Pediatric Neurology·R N ChoueiriM A Mikati
Oct 9, 2002·Epilepsia·E AndersonUNKNOWN ILAE Genetics Commission
Sep 27, 2003·Epilepsia·Lauren C Frey
May 12, 2006·The Neurologist·Panayiotis N Varelas, Marianna Spanaki
Dec 20, 2005·Epilepsia·Ruth Ottman
Nov 28, 2009·Epilepsia·Paula Elyse Schauwecker
May 31, 2012·Epilepsia·UNKNOWN Epi4K Consortium
Jan 29, 2014·Brain : a Journal of Neurology·Anna L PeljtoRuth Ottman
Oct 7, 1998·Brain & Development·S L Kugler, W G Johnson
Jun 15, 2007·Expert Review of Neurotherapeutics·Danielle M Andrade, Berge A Minassian
Apr 6, 2012·Epilepsy Research·Sylwia Misiewicz, Melodie R Winawer
Dec 14, 2002·Mayo Clinic Proceedings·Maria Augusta MontenegroFernando Cendes
May 26, 2009·Seizure : the Journal of the British Epilepsy Association·Krista MahoneyTerry-Lynn Young
Apr 5, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·B XiaoH-W Deng
Oct 26, 2005·Human Molecular Genetics·John C MulleyLeanne M Dibbens
Oct 6, 2000·Arquivos de neuro-psiquiatria·E KobayashiI Lopes-Cendes
Jan 14, 2021·Brain : a Journal of Neurology·Kasper LolkJakob Christensen
Feb 1, 2005·Epilepsia·Ruth OttmanChristie Barker-Cummings

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