PMID: 6168434Oct 1, 1981Paper

Clinical indicators of prognosis in unresected lung cancer

Chest
P CoyA J Coldman

Abstract

A prognosis estimate in palliative treatment for inoperable lung cancer is thought to be of value. Performance status is now recognized as being of major importance, but only recently has been consistently available. We examined other simple information not requiring clinical or laboratory tests that is available in the clinical histories of a series of 1,839 patients with unresected lung cancer. Actuarial survivals at 1, 2, and 5 years were 21.9, 7.8, and 2.0 percent, respectively. The median survival rate was 24 weeks. Squamous cell histology and an increasing interval between the first symptoms and diagnosis were associated with a better prognosis. The number of symptoms recorded at the time of assessment had strong negative association with survival; asymptomatic patients had a two-year survival of 26 percent compared with 6 percent or less with four or more symptoms. A similar discrimination is given by Feinstein's index, which combines information on the number and type of symptoms and on the interval between first symptom and diagnosis. The clinical stage was strongly related to survival. Additional statistical analysis showed that the prognostic value of each of the most powerful prognostic factors, the number of sympto...Continue Reading

References

May 20, 1967·Lancet·J R BignallD W Smithers
Sep 1, 1973·Chest·L HydeR Yesner

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Citations

Dec 21, 2000·Current Oncology Reports·C J Langer
Dec 1, 1995·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M FurutaH Niibe
May 1, 1997·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A CharlouxE Quoix
Jan 1, 1990·Journal of Clinical Epidemiology·R S PhillipsW A Knaus
Dec 11, 1990·Cancer Treatment Reviews·S A Rosenthal, W J Curran
Apr 3, 2004·Technology in Cancer Research & Treatment·M O Maiwand, G Asimakopoulos
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M H CullenR L Souhami

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