Clinical interest of fMRI and functional exploration methods of brain activity and interactivity: physical and neurophysiological considerations

Journal of Neuroradiology. Journal De Neuroradiologie
G de MarcoJ Chiras

Abstract

After having provided a brief reminder of the principle of the blood oxygen level-dependent (BOLD) contrast effect, the physiological bases of brain activity and the concepts of functional integration and effective connectivity, we describe the most recent approaches, which permit to explore brain activity and putative networks of interconnected active areas in order to examine the normal brain physiology and its dysfunctions. We present various methods and studies of brain activity analysis clinically applicable, and we detail the concepts of functional and effective connectivity, which allow to study the cerebral plasticity which occurs at the child's during the maturation (e.g., dyslexia), at the adult during the ageing (e.g., Alzheimer disease), or still in schizophrenia or Parkinson disease. The study of specific circuits in networks has to allow defining in a more realistic way the dynamic of the central nervous system, which underlies various cerebral functions, both in physiological and pathological conditions. This connectivity approach should improve the diagnostic and facilitate the development of new therapeutic strategies.

References

Jan 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K J FristonR S Frackowiak
Jul 23, 1998·Human Brain Mapping·M J McKeownT J Sejnowski
Oct 19, 1999·Human Brain Mapping·K FristonC Büchel
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·G D HoneyT Sharma
Nov 26, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·H P ZaveriS S Spencer
Nov 9, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·R I GoldmanM S Cohen
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·D A GusnardM E Raichle
Feb 12, 2002·Nature Reviews. Neuroscience·David J Heeger, David Ress
Jun 22, 2002·Brain : a Journal of Neurology·Patrizia PantanoGian Luigi Lenzi
Dec 19, 2002·NMR in Biomedicine·Peter J Basser, Derek K Jones
Jan 4, 2003·Radiology·Kader Karli OguzDavid M Yousem
Feb 21, 2003·Journal of Magnetic Resonance Imaging : JMRI·Karsten MüllerD Yves von Cramon
Nov 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Cindy LustigRandy L Buckner
Dec 3, 2003·Radiology·Setsu WakanaSusumu Mori
Nov 1, 1949·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·C O HEBB, H KONZETT
Jan 18, 2006·NeuroImage·Elena RykhlevskaiaGabriele Gratton
May 2, 2006·Journal of Magnetic Resonance Imaging : JMRI·Richard G Wise, Irene Tracey
May 2, 2006·Journal of Magnetic Resonance Imaging : JMRI·Noam HarelEssa Yacoub
May 2, 2006·Journal of Magnetic Resonance Imaging : JMRI·Cornelius WeillerMichel Rijntjes
Mar 21, 2007·NeuroImage·Randy L Buckner, Justin L Vincent
Apr 22, 2008·Neurophysiologie clinique = Clinical neurophysiology·V QuaglinoG de Marco

❮ Previous
Next ❯

Citations

Dec 15, 2015·International Ophthalmology·Shikha GuptaPradeep Sharma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.