PMID: 42597Oct 1, 1979

Clinical investigation of serum deoxyribonuclease: I. Analysis of serum deoxyribonuclease activity in comparison with normal and after endoscopic retrograde pancreatography

Gastroenterologia Japonica
A FunakoshiH Ibayashi


Serum Deoxyribonuclease (DNase) micro-assay method was developed using 32P-labelled E. coli DNA as substrate. The serum DNase showed maximum activity at pH 7.5. It required Mg+ for activity, and was inhibited by EDTA or EGTA. The enzyme was also inhibited by actin (60-65%) or bovine pancreatic DNase I antibody (40-45%). The serum DNase activity was markedly increased following endoscopic retrograde pancreatography (ERP) examination. These results imply that serum DNase activity is mostly at least 60-65% pancreatic DNase I.


Dec 1, 1977·Journal of Biochemistry·A FunakoshiY Takagi
Dec 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·E Lazarides, U Lindberg
Apr 1, 1970·European Journal of Biochemistry·M U Lindberg, L Skoog
Feb 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·T LindahlG M Edelman
Nov 1, 1952·The Journal of General Physiology·V ALLFREY, A E MIRSKY
Aug 1, 1953·Biochimica Et Biophysica Acta·L CUNNINGHAM, M LASKOWSKI
Nov 1, 1956·Biochimica Et Biophysica Acta·M GOUTIER-PIROTTE, A OTH
Dec 1, 1956·The Journal of Clinical Investigation·O D KOWLESSAR, R K MCEVOY
Apr 1, 1963·Archives of Biochemistry and Biophysics·S GUPTA, R M HERRIOTT

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