Clinical judgement in precision medicine

Journal of Evaluation in Clinical Practice
Mark R Tonelli

Abstract

Precision medicine, which aims to individualize care based upon the unique combination of genetic, environmental, and lifestyle features in particular patients, will require an evolution in clinical decision making. Practitioners of precision medicine will need to utilize an expanded body of medical knowledge derived from a wide variety of sources. Clinical judgement in the case-based reasoning necessary for individualizing care will involve understanding and utilizing methodological approaches not commonly invoked in medicine, including mechanistic and qualitative research results. Instead of searching for an answer in the published literature, precision medicine demands clinical judgement that finds the reasons for clinical decisions within, not without, the patient.

References

Jul 1, 1996·Journal of Clinical Epidemiology·D C HadornN Hicks
Sep 1, 1995·Kennedy Institute of Ethics Journal·Albert R Jonsen
May 26, 2006·Journal of Evaluation in Clinical Practice·Mark R Tonelli
Jan 31, 2015·The New England Journal of Medicine·Francis S Collins, Harold Varmus
Jul 28, 2015·Studies in History and Philosophy of Biological and Biomedical Sciences·Jonathan Fuller, Luis J Flores
Oct 16, 2016·Trends in Molecular Medicine·Brian H ShirtsTom Walsh
Oct 21, 2017·JAMA : the Journal of the American Medical Association·Mark R Tonelli, Brian H Shirts

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Citations

Apr 25, 2018·Journal of Evaluation in Clinical Practice·Benjamin Chin-Yee, Jonathan Fuller

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