Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease.

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Brent A Neuschwander-TetriNASH Clinical Research Network

Abstract

The Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) was formed to conduct multicenter studies on the etiology, contributing factors, natural history, and treatment of nonalcoholic steatohepatitis (NASH). The aim of this study was to determine the associations of readily available demographic, clinical, and laboratory variables with the diagnosis of NASH and its key histological features, and determine the ability of these variables to predict the severity of nonalcoholic fatty liver disease (NAFLD). A total of 1266 adults were enrolled in NASH CRN studies between October 2004 and February 2008, of whom 1101 had available liver histology. The median age was 50 years; 82% were white and 12% Hispanic. The median body mass index was 33 kg/m(2); 49% had hypertension and 31% had type 2 diabetes. On liver biopsy, 57% were judged to have definite NASH and 31% bridging fibrosis or cirrhosis. Using data from the 698 patients with liver biopsies within 6 months of clinical data, patients with definite NASH were more likely to be female and have diabetes, higher levels of aspartate and alanine aminotransferases, alkaline phosphatase, gamma glutamyl transpeptidase, and homeostasis model assessment of insulin resistance (HO...Continue Reading

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References

Jun 2, 2000·Gastroenterology·V RatziuT Poynard
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Jul 3, 2002·Annals of Internal Medicine·Daniele PratiGirolamo Sirchia
Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brent A Neuschwander-Tetri, Stephen H Caldwell
May 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pouneh MofradArun J Sanyal
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Tao WaiAnna S-F Lok
Jan 7, 2004·Digestive Diseases and Sciences·Paola LoriaNicola Carulli
Jul 6, 2004·The American Journal of Gastroenterology·Leon A AdamsPaul Angulo
Sep 15, 2004·Journal of Clinical Gastroenterology·Scott J CotlerShriram Jakate
May 17, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giorgio BedogniStefano Bellentani
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Jun 9, 2005·Gastroenterology·Vlad RatziuUNKNOWN LIDO Study Group
Feb 2, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Nicole A PalekarStephen A Harrison
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Raphael B MerrimanNathan M Bass
Feb 22, 2007·The American Journal of Gastroenterology·Pierre M GholamDonald P Kotler
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul AnguloChristopher P Day
Jul 31, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna WieckowskaAriel E Feldstein
Nov 3, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Hisamitsu MiyaakiKatsumi Eguchi
Mar 5, 2008·Annals of Internal Medicine·Mariana LazoJeanne M Clark
Mar 26, 2008·Archives of Internal Medicine·Brent A Neuschwander-TetriUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Mar 28, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W Ray KimUNKNOWN Public Policy Committee of the American Association for the Study of Liver Disease
Apr 25, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guilherme M CamposRaphael B Merriman
Oct 29, 2008·Seminars in Liver Disease·Anna Wieckowska, Ariel E Feldstein
Nov 18, 2008·Gastroenterology·Heather M PattonUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Jun 16, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Amy G ShahUNKNOWN Nash Clinical Research Network
Jun 16, 2009·Gastroenterology·Anna KotronenHannele Yki-Järvinen
Sep 19, 2009·Contemporary Clinical Trials·Joel E LavineUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network Research Group
Apr 30, 2010·The New England Journal of Medicine·Arun J SanyalUNKNOWN NASH CRN

❮ Previous
Next ❯

Citations

Nov 30, 2011·Current Gastroenterology Reports·James E NelsonKris V Kowdley
May 23, 2012·Nature Reviews. Gastroenterology & Hepatology·Elena Reynoso, Joel E Lavine
Mar 6, 2013·Nature Reviews. Gastroenterology & Hepatology·Geoffrey C FarrellShiv Chitturi
Mar 16, 2012·Seminars in Liver Disease·Hemant ChatrathNaga Chalasani
Jan 21, 2011·Current Opinion in Gastroenterology·Paul J Clark, Keyur Patel
Nov 22, 2011·BMJ : British Medical Journal·Mariana LazoJeanne M Clark
Aug 13, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michael CharltonGregory Gores
Nov 24, 2011·Experimental Diabetes Research·Mikako Obika, Hirofumi Noguchi
Nov 14, 2012·Therapeutic Advances in Endocrinology and Metabolism·Romina LomonacoKenneth Cusi
Aug 23, 2012·World Journal of Gastroenterology : WJG·Neven BaršićMarko Duvnjak
Dec 24, 2013·World Journal of Gastroenterology : WJG·Srinevas K ReddySamer S El-Kamary
Feb 18, 2012·The American Journal of Clinical Nutrition·Anthony L GuerrerioAnn O Scheimann
Mar 14, 2014·Journal of Medicinal Chemistry·Makonen BelemaNicholas A Meanwell
Nov 30, 2013·Endocrine·Joseph M PappachanArjun Mukherjee
Jul 16, 2014·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Shahinul AlamA K M Khorshed Alam
May 10, 2012·Gut and Liver·Geoffrey C FarrellShivrakumar Chitturi
Nov 28, 2013·Journal of Gastroenterology·Takashi NakaharaUNKNOWN Japan Study Group of Nonalcoholic Fatty Liver Disease
May 9, 2013·Current Opinion in Organ Transplantation·Michael Charlton
Feb 27, 2015·Expert Review of Gastroenterology & Hepatology·Amanda Tamar SchneierDouglas T Dieterich
Apr 12, 2011·Expert Review of Gastroenterology & Hepatology·Mariana Verdelho Machado, Helena Cortez-Pinto
Apr 12, 2011·Expert Review of Gastroenterology & Hepatology·R Christopher HarmonCurtis K Argo
Apr 12, 2016·Clinics in Liver Disease·Paul D Berk, Elizabeth C Verna
Mar 22, 2016·Metabolism: Clinical and Experimental·Yousef FazelZobair M Younossi
Nov 28, 2013·Clinics in Liver Disease·Zachary D Goodman
Aug 8, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Charlotte de JongeJan Willem M Greve
Jul 25, 2012·Clinics in Liver Disease·Evelyn Hsu, Karen Murray
Mar 29, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Zobair M YounossiManirath Srishord
Apr 12, 2016·Clinics in Liver Disease·David E Kleiner, Hala R Makhlouf
Dec 18, 2015·BBA Clinical·George Boon-Bee GohArthur J McCullough
Jan 1, 2015·Nature Reviews. Disease Primers·Elizabeth M BruntMary E Rinella
Aug 25, 2015·Gastroenterology·Rohit LoombaUNKNOWN Genetics of NAFLD in Twins Consortium
Oct 24, 2015·Nutrition Research Reviews·D T Reid, B Eksteen

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