Clinical Lipidology and the Prevention of Vascular Disease: Time for Personalized Therapy

Clinical Pharmacology and Therapeutics
William Virgil Brown

Abstract

Genetic, metabolic, and lifestyle modifications can cause elevations of lipoproteins that contribute to atherosclerotic lesions over time. In the modern world with life extension from many improvements in medicine and public health, most humans live long enough to develop atherosclerosis with concentrations of blood plasma lipoproteins that are very common. Familial abnormalities are prevalent and provide additional challenges in identifying unhealthy but treatable values of low-density (LDL) and very low-density lipoproteins (VLDL). Multiple community studies and clinical trials have provided guidance on selecting targets and new tools that make possible effective goals of treatment. Lipid-lowering drugs are making it possible to achieve those goals and place responsibility on physicians to master the art of preventing atherosclerotic events. Lipoprotein management remains a very focused effort and requires an artful individualized approach for each patient. Few skills are more important for healthcare providers in primary care and cardiovascular medicine.

References

Jul 1, 1978·The American Journal of Clinical Nutrition·W E ConnorH R Casdorph
Nov 1, 1991·The Journal of Clinical Endocrinology and Metabolism·R A Lobo
Jan 1, 1986·Clinics in Dermatology·H GinsbergW V Brown
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·M S Brown, J L Goldstein
May 6, 2003·Nature Genetics·Marianne AbifadelCatherine Boileau
Jul 16, 2003·The American Journal of Cardiology·Peter H JonesUNKNOWN STELLAR Study Group
Feb 11, 2004·Circulation·G SalenUNKNOWN Multicenter Sitosterolemia Study Group
Jun 17, 2004·Seminars in Vascular Medicine·Adrian David MaraisDirk Jacobus Blom
Sep 11, 2004·Journal of the American College of Cardiology·Scott M GrundyUNKNOWN Coordinating Committee of the National Cholesterol Education Program
Jan 22, 2005·Fundamental & Clinical Pharmacology·Michael Schachter
May 6, 2005·Clinical Pharmacokinetics·Teddy KosoglouKevin B Alton
Nov 4, 2005·Medicine·Giorgia MelliDavid R Cornblath
Mar 24, 2006·The New England Journal of Medicine·Jonathan C CohenHelen H Hobbs
Oct 4, 2006·Pediatrics·C Alex McMahanUNKNOWN Pathobiological Determinants of Atherosclerosis in Youth Research Group
Jun 30, 2007·Drugs·Bart Staels, Folkert Kuipers
Dec 26, 2007·The American Journal of Cardiology·Noa HoloshitzRichard H Karas
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel
Jul 1, 2008·Atherosclerosis. Supplements·Harry R DavisScott W Altmann
Mar 25, 2009·Archives of Internal Medicine·Earl S FordAli H Mokdad
Mar 17, 2010·The New England Journal of Medicine·Henry N GinsbergRobert P Byington
Nov 3, 2010·Journal of Lipid Research·Christopher T JohansenRobert A Hegele
Aug 1, 2007·Journal of Clinical Lipidology·Allan SnidermanPatrick Couture
May 18, 2011·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Michel P Hermans
Jan 14, 2012·Journal of Internal Medicine·R P SurendranG M Dallinga-Thie
Sep 11, 2012·The Journal of Clinical Endocrinology and Metabolism·Lars BerglundUNKNOWN Endocrine society
Jan 16, 2013·Current Pharmaceutical Design·Catherine GebhardJean-Claude Tardif
Nov 19, 2013·Journal of the American College of Cardiology·Neil J StoneUNKNOWN American College of Cardiology/American Heart Association Task Force on Practice Guidelines

❮ Previous
Next ❯

Citations

Aug 18, 2018·Clinical Pharmacology and Therapeutics·John Vincent
Oct 19, 2019·Biological Reviews of the Cambridge Philosophical Society·Xin Su, Daoquan Peng

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.