Clinical management and immunohistochemical analysis of umbilical endometriosis

Archives of Gynecology and Obstetrics
Sylvia MechsnerAndreas Ebert

Abstract

To established a strategy for diagnostic and therapeutic management of umbilical endometriosis and to determine the biological character. Clinical examination, vaginal and abdominal ultrasound, magnetic resonance imaging of the abdominal wall and laparoscopy were performed on a 42-year-old woman with umbilical endometriosis. Surgery with umbilical reconstruction was performed by a new plastic surgery technique. Immunohistochemical analyses (against Ki 67, estrogen/progestogen receptor, CD10, smooth muscle actin, desmin, caldesmon, von Willebrandt factor, cyclooxygensae-2 and VEGF) were done to characterize the umbilical endometriotic lesion. The extension of the endometriotic lesion necessitated total removal of the umbilicus. Umbilical reconstruction was performed by a new plastic surgery technique. The lesion did express CD10, estrogen and progestogen receptors, and did show a moderate proliferation rate. Furthermore, signs of metaplastic processes such as smooth muscle metaplasia and angiogenesis were detected. The endometriotic lesion was positive not only for smooth muscle actin, caldesmon and desmin, but also for COX-2 and VEGF. Based on a case report and a literature review, we discuss the diagnostic and therapeutic mana...Continue Reading

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Citations

Dec 1, 2009·International Journal of Surgery·Luigi FedeleNevio Ciappina
Jun 16, 2014·Archives of Gynecology and Obstetrics·Anuradha Ghosh, Sachchidananda Das
Jul 15, 2015·Taiwanese Journal of Obstetrics & Gynecology·Gloria CalagnaAntonino Agrusa
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Jul 3, 2021·Cells·Teresa Mira Gruber, Sylvia Mechsner

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