Clinical management and survival outcomes of gliosarcomas in the era of multimodality therapy

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Omprakash DamodaranGabriel Lee

Abstract

Gliosarcoma (GSM) is a rare primary malignant brain tumour accounting for less than 0.5% of all intracranial tumours. It has a biphasic histological composition, demonstrating both gliomatous and sarcomatous elements. In clinical practice GSM are generally managed similarly to glioblastoma multiforme (GBM). However, unique features including its clinical propensity for extra-cranial metastasis, distinct radiological features and possible worse prognosis than GBM suggest that GSM may be a distinct clinico-pathological entity. Hence we reviewed patterns of care and outcomes for a series of Australian patients diagnosed with GSM in the era of combined chemo-radiotherapy. Patients were identified by searching the Australian Genomics and Clinical Outcomes of Glioma (AGOG) database and the Western Australian Interhospital Neurosurgical database. Nineteen patients with GSM were identified. Of these, 15 patients were diagnosed with primary GSM and four patients developed secondary GSM after radiation therapy for primary GBM. For comparative purposes, 408 primary GBM patients were identified from the AGOG database during the same study period. The overall median survival for all primary GSM patients was 9.7 months. In comparison the ove...Continue Reading

References

Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Dec 5, 2008·Journal of Cancer Research and Therapeutics·Piyush KumarNiloy R Datta
May 5, 2009·Journal of Neurosurgery·Seunggu J HanAndrew T Parsa
May 20, 2011·British Journal of Neurosurgery·Ahitagni BiswasSuresh Narain Mathuriya
Nov 16, 2011·Journal of Computer Assisted Tomography·Bi-Yun ZhangXiao-Qiang Wang
Dec 27, 2011·Cell Biochemistry and Biophysics·LiZhao ChenMinHui Xu

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Citations

Aug 11, 2015·Frontiers in Oncology·Tracy SeymourFoteini Kakulas
May 7, 2016·Journal of Neurosurgery·Jason K HsiehAndrew E Sloan
Mar 7, 2017·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Rajalakshmi PoyuranAmey R Savardekar
Jun 18, 2017·Journal of Neurosurgery·Jonathan FrandsenGita Suneja
Jun 24, 2017·The Neuroradiology Journal·Luísa SampaioJosé Fonseca
Nov 21, 2017·Journal of Neurosurgical Sciences·Ruichong MaErlick A Pereira
Mar 31, 2016·Journal of Neuro-oncology·Sebastian AdebergJuergen Debus
Jun 28, 2018·European Radiology·Xiaoping YiXuejun Li
Jan 6, 2017·Case Reports in Radiology·Quoc-Bao D NguyenJamie J Van Gompel
May 14, 2016·Journal of Neuro-oncology·J CastelliG Noel
Jan 22, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Tavarekere N Nagaraja, Ian Y Lee
Feb 5, 2021·British Journal of Neurosurgery·Bujung HongJoachim K Krauss
May 1, 2021·The Neuroradiology Journal·Christoph J MaurerRoland Roelz

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