Clinical Management of Antipsychotic-Induced Hyperprolactinemia

Perspectives in Psychiatric Care
Choochart Wong-Anuchit

Abstract

This article describes the physiology and mechanisms of prolactin and the assessment and clinical management strategies of antipsychotic-induced hyperprolactinemia. Hyperprolactinemia is a disorder of the hypothalamic-pituitary axis which can be caused by several mechanisms. Typical antipsychotic agents are more likely to cause hyperprolactinemia than atypical antipsychotic agents, with the exception of amisulpride, paliperidone, and risperidone. Switching from prolactin-elevating to prolactin-sparing agents is recommended. Providing adjunctive treatment and prescribing substitutive hormones are alternatives. Education and lifestyle modification should be a major health promotion strategy. Taking patients' history and conducting physical examinations should be done during follow-up.

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Jun 28, 2016·Expert Opinion on Drug Safety·L OrsoliniD De Berardis
Jan 16, 2018·International Journal of Psychiatry in Clinical Practice·Fahad D AlosaimiMohammed Z Alassiry

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