PMID: 11605170Oct 18, 2001Paper

Clinical management of beta-thalassemia major

Seminars in Hematology
Beatrix Wonke

Abstract

Management of patients with beta-thalassemia is based on adequate, safe blood transfusions (free of transfusion-transmitted diseases) and prevention of iron overload. Iron overload causes multiple endocrinopathies, contributes to osteoporosis, and is the cause of cardiac disease. Cardiac disease, secondary to iron damage, causes death in developed countries as a result of noncompliance to deferoxamine from the third decade of life. In underdeveloped countries, cardiac death starts from 12 years of age, due to nonavailability of deferoxamine. With the emergence of the advanced cardiac magnetic resonance imaging technique, early diagnosis of heart iron will allow the currently available iron-chelating agents (oral and parenteral) to be used in an innovative way to improve the quality of life and improve survival of patients with beta-thalassemia.

Citations

Feb 25, 2005·European Journal of Drug Metabolism and Pharmacokinetics·Jasmina NovakovicMichael Spino
Feb 16, 2005·Annals of Hematology·Athanasios AessoposEfstathios Papalambros
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Nicoletta BianchiRoberto Gambari
Mar 12, 2011·Journal of Paediatrics and Child Health·Way Seah LeeThian Lian Soo
Jun 21, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·L GrecoD Angilletta
Jan 22, 2005·Annual Review of Medicine·Stanley L Schrier, Emanuele Angelucci
Jul 28, 2009·Annual Review of Medicine·Maria Domenica Cappellini, Paolo Pattoneri
Mar 25, 2008·Therapeutics and Clinical Risk Management·Maria Domenica Cappellini
Oct 6, 2004·British Journal of Haematology·Ersi Voskaridou, Evangelos Terpos
Jan 19, 2005·European Journal of Haematology·Shlomit ShalitinHannah Tamary
Feb 13, 2003·Pediatric Clinics of North America·Louise Lo, Sylvia Titi Singer
May 6, 2008·Experimental Hematology·Natasha SzuberPrem Ponka
Aug 22, 2008·Indian Journal of Pediatrics·A P DubeyS Dublish
Dec 26, 2008·Blood·Mitchell J Weiss, Camila O dos Santos
May 13, 2014·Genome Biology and Evolution·Michael J GaudryFederico G Hoffmann
Mar 8, 2006·World Journal of Gastroenterology : WJG·Themistoklis VassiliadisNikolaos Eugenidis
Aug 4, 2010·Pediatric Hematology and Oncology·Gunseli BozdoganYildiz Yildirmak
Apr 5, 2016·Pharmacogenomics·Jessica CusatoAntonio D'Avolio
May 9, 2007·Hemoglobin·Gülsen Bozkurt
May 12, 2011·Toxicologic Pathology·Pramod S TerseJoseph E Tomaszewski
Feb 1, 2011·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Giorgio DerchiGian Luca Forni
Aug 19, 2014·Hematology·Azita AzarkeivanParvin Lotfi
Aug 30, 2008·Pediatric Hematology and Oncology·Azita AzarkeivanParvaneh Vosough
Aug 23, 2011·Pediatric Hematology and Oncology·Azita AzarkeivanMitra Salahmand
Mar 12, 2016·The Cochrane Database of Systematic Reviews·Amit BhardwajIfeyinwa Osunkwo
Jun 10, 2005·Journal of Medicinal Chemistry·Raymond J BergeronLaszlo Prokai
Dec 28, 2002·Journal of Medicinal Chemistry·Raymond J BergeronJames S McManis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Jasmina NovakovicJake Thiessen
British Journal of Haematology
K Konstantopoulos, S Lymperi
Blood Transfusion = Trasfusione Del Sangue
Roberto Gambari
American Journal of Hematology
Felicia TrachtenbergThalassemia Clinical Research Network
© 2021 Meta ULC. All rights reserved