Clinical management of infants with hypoplastic left heart syndrome in the United States, 1988-1997

Ruey-Kang R ChangThomas S Klitzner


To evaluate changes in the clinical management of infants with hypoplastic left heart syndrome (HLHS) over a 10-year period. Orthotopic heart transplantation (OHT) and the Norwood procedure have emerged as the treatment options for HLHS over the last 2 decades. We used 1988-1997 hospital discharge data from the National Inpatient Sample dataset. Patients < or =30 days of age with a principal diagnosis of HLHS were identified. Clinical management included the Norwood procedure, OHT, in-hospital death without surgery, discharge home without surgery, and transfer to another hospital. Multivariate logistic regression was used to evaluate variables associated with the choice of management. There were 1986 cases of HLHS with 812 in-hospital deaths, yielding a mortality rate 40.9%. The in-hospital mortality rate decreased from 54.4% in 1988 to 38.1% in 1997. The proportion of patients treated with the Norwood procedure increased from 8% in 1988 to 34% in 1997. The proportion of patients who died in the hospital without surgery decreased over time while the percentage discharged from the hospital without surgery or transferred to another hospital remained relatively unchanged. The in-hospital mortality rate was significantly lower in t...Continue Reading


Apr 28, 2009·Pediatric Cardiology·Alexander A Kon
Apr 24, 2010·Pediatric Cardiology·Lauren B RosenthalLisa Saiman
Dec 12, 2003·Surgery·Brian D SaundersPaul G Gauger
Jul 25, 2003·Pediatric Neurology·Roshan RajaStephen Ashwal
Mar 6, 2004·Seminars in Neonatology : SN·Caren S Goldberg, Carlen A Gomez
Jul 13, 2004·Cardiology in the Young·Martin J Elliott
Sep 9, 2005·Critical Care Medicine·John M TilfordP David Adelson
Jan 8, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Susan R HintzUNKNOWN ELSO Registry
Nov 23, 2006·Intensive Care Medicine·Sylvie Di FilippoRicardo Muñoz
Aug 30, 2012·Indian Heart Journal·Snehal Kulkarni, Suresh Rao
May 25, 2010·The Annals of Thoracic Surgery·Angira PatelConstantine D Mavroudis
Nov 17, 2009·The Journal of Thoracic and Cardiovascular Surgery·Tara KaramlouKarl F Welke
Jun 7, 2008·The Journal of Pediatrics·Brent M GordonRuey-Kang Chang
Oct 24, 2007·The Annals of Thoracic Surgery·Jenifer A GlatzJack Rychik
Feb 19, 2008·Journal of Pediatric Surgery·Randolph K CribbsMark L Wulkan
Apr 9, 2005·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Amy H Schultz, Gil Wernovsky
Jul 31, 2004·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Shunji SanoOsami Honjo
Mar 12, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·William E HarmonMary K Guidinger
Jul 21, 2007·Journal of Paediatrics and Child Health·James TibballsJim Wilkinson
Sep 10, 2014·Congenital Heart Disease·Ritu BhardwajBhagyalaxmi Mohapatra
Feb 26, 2011·The Journal of Pediatrics·Jennifer C HirschJames G Gurney
Nov 13, 2014·Current Opinion in Cardiology·Daniel J DiBardino
Jun 22, 2007·Qualitative Health Research·Gwen R Rempel, Margaret J Harrison
Oct 19, 2004·World Journal of Surgery·Brian D SaundersPaul G Gauger
Jul 9, 2004·Cardiology in the Young·Robin R Fountain-DommerGirish S Shirali
Jul 3, 2019·Pediatrics in Review·Rabia JavedMuhammad Yasir Qureshi
Mar 26, 2003·Current Opinion in Cardiology·Daniel S LeviJohn W Moore
Nov 23, 2020·Journal of Clinical Psychology in Medical Settings·Rachel E SicilianoLori C Jordan

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.