Clinical manifestations and laboratory assessment in an enterovirus 71 outbreak in southern Taiwan

Scandinavian Journal of Infectious Diseases
Chung-Chen LiKuender D Yang

Abstract

An epidemic of enterovirus 71 (EV71) infection compatible with hand, foot and mouth disease and associated with high morbidity and mortality occurred in Taiwan in 1998. We recruited 90 patients (50 males, 40 females) with definite EV71 infections for clinical and laboratory analysis. The neurological signs and symptoms, all of which occurred during the febrile period, in patients with central nervous system (CNS) involvement (aseptic meningitis, encephalitis or myelitis) were myoclonic jerks (23/33), vomiting (10/33), ataxia (7/33), lethargy (6/33), seizure (4/33) and tremor (2/33). Patients with CNS involvement had longer durations of fever (4.6+/-0.2 vs. 3.1+/-0.3 d; p <0.01) and a higher white blood cell count (12,512+/-658 vs. 10,607+/-409 cells/mm3; p = 0.01) than patients without CNS involvement. The case fatality rate in patients with CNS involvement was 4/33 (12%), whereas no fatalities (0/57) occurred in patients without CNS involvement. Six of 11 patients subjected to MRI showed a high intensity T2-weighted signal in the brainstem. A nested fluorescent RT-PCR for detection of virus in throat and stool specimens showed higher sensitivity than viral culture. Viremia was detectable using RT-PCR in 20% of cases (3/15), wh...Continue Reading

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Citations

Jan 9, 2010·Epidemiology and Infection·S S Y WongK Y Yuen
Sep 1, 2011·Epidemiology and Infection·M ZengQ-R Zhu
Sep 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carlos M Pérez-VélezMary P Glodé
Jun 14, 2013·Journal of Virology·Hsiang-Yin LinYen-Hung Chow
Apr 2, 2014·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Mei ShiWeifeng Shi
Jun 5, 2015·The Kaohsiung Journal of Medical Sciences·Chia-Feng YehJung-San Chang
Jul 8, 2008·Journal of Ethnopharmacology·Jung San ChangLien Chai Chiang
Jun 20, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Kuang-Che KuoChen-Hsiang Lee
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