Clinical manifestations and management of labor and delivery in women with factor IX deficiency

Haemophilia : the Official Journal of the World Federation of Hemophilia
M Y Yang, M V Ragni

Abstract

Haemophilia is uncommon in females and little is known about the clinical manifestations and postpartum management of women with this disorder. Clinical characteristics of postpartum bleeding were evaluated in women with factor IX deficiency (FIX:C < 0.20 U mL(-1)), including two with haemophilia B and three carriers of haemophilia B, undergoing labour and delivery. Data were collected prospectively during routine outpatient comprehensive haemophilia care at the haemophilia Center of Western Pennsylvania and during inpatient management. Four of five women experienced postpartum bleeding, during six of 16 deliveries: the median haemoglobin was 10.7 g% and two required blood transfusion. Postpartum bleeding was significantly more common among those receiving fewer than 4 days of FIX replacement: six of 13 (46.1%) receiving fewer three or fewer days bled vs. none of three (0%) receiving six or more days treatment [P < 01 (Wilcoxon)]. Postpartum bleeding was not related to the route of delivery (P = 0.525), vaginal vs. Caesarean, nor the FIX level (P = 0.371; FIX > 0.05 U mL(-1) vs. < or =0.05 U mL(-1)). Compared with females with von Willebrand disease or FXI deficiency, females with FIX deficiency were more likely to experience p...Continue Reading

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Citations

Oct 29, 2013·Annales Françaises D'anesthèsie Et De Rèanimation·A BonnetF Aubrun
Jul 15, 2009·Journal de gynécologie, obstétrique et biologie de la reproduction·E de Raucourt, C Ternisien
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Jul 14, 2005·Haemophilia : the Official Journal of the World Federation of Hemophilia·A H James
Aug 30, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·A SharathkumarA Shapiro
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Feb 19, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·D M Di MicheleA Ganguly
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Sep 29, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Roseline d'OironAndra H James
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Dec 15, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Connie H Miller, Christopher J Bean

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