Clinical manifestations of Campylobacter jejuni infection in adolescents and adults, and change in antibiotic resistance of the pathogen over the past 16 years

Scandinavian Journal of Infectious Diseases
Feng-Qin HouGui-Qiang Wang

Abstract

Campylobacter jejuni infection, traditionally a paediatric illness, is now seen more frequently in adolescents and adults in northern China. Published surveillance reports on C. jejuni infection in these patients are rare. We aimed to characterize (1) the clinical manifestations of this infection in adolescents and adults, and (2) changes in antibiotic resistance of the pathogen. We retrospectively examined 492 cases of C. jejuni infection in patients aged ≥ 14 y treated at the Peking University First Hospital, Beijing, China, for the period January 1994 to December 2010. The disease was more common in patients aged 14-24 y and in men (57.9%; p < 0.0001 vs women). The peak incidence was seen between May and October. The infection manifested with acute diarrhoea (< 10 bowel movements per day, loose or mucous stool), fever (mostly low grade), and abdominal cramps and pain. Faecal leukocytes and erythrocytes were demonstrated in, respectively, 90.9% and 79.3% of stool specimens, while leukocytes > 10 per high-power field were detected in 70.3%. In 1994-1998, 44.5% of C. jejuni strains were resistant to fluoroquinolone, 0% to gentamicin, and 0% to cefuroxime; in 2005-2010, resistance increased significantly to 97.9%, 16.7%, and 93....Continue Reading

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Citations

Sep 17, 2013·The American Journal of Medicine·Ami Schattner
Aug 19, 2015·Enfermedades infecciosas y microbiología clínica·Ana González-TorralbaJuan-Ignacio Alós
Nov 14, 2018·Antimicrobial Agents and Chemotherapy·Francesca SchiaffinoMargaret N Kosek
Apr 10, 2018·Korean journal of pediatrics·Joon Yeol BaeJung Min Yoon

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