Clinical Manifestations of Isolated Elevated Homocysteine-Induced Peripheral Neuropathy in Adults

Journal of Clinical Neuromuscular Disease
Varun Shandal, Jin Jun Luo

Abstract

To characterize the clinical features of isolated elevated plasma homocysteine (eHcy)-induced peripheral neuropathy (IHIN) in adults. Charts of subjects with the diagnosis of IHIN who visited neuromuscular clinic from January 01, 2012 to September 30, 2014 were reviewed. Subjects with identifiable etiologies for neuropathy, such as B12/folate deficiency; metabolic, toxic, endocrinologic, infectious/inflammatory renal or liver diseases; or traumatic nerve injury, were excluded. Their clinical presentations were recorded and analyzed. Thirty subjects (age: 63.2 ± 14.8 years, 13 males) were included. They all had an isolated increased homocysteine level (15.4 ± 5.3 μmol/L) but normal levels of B12, folate, and methylmalonic acid. Of 30, 14 (46.7%) had numb feet, 11 (36.7%) had numb hands, 7 (23.3%) had pain in lower extremities, and 10 (33.3%) had tingling in feet. Distal sensory deficits were present in 18/30 (60%) patients. Distal limb weakness was seen in 4 and decreased tendon reflexes in 12 patients. Sensory deficits are predominant components of IHIN. Characterizing clinical features of IHIN would help better understand eHcy-related neuropathy and improve its management.

References

Aug 17, 1999·Annual Review of Nutrition·J Selhub
Apr 25, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·A AmbroschH Lehnert
Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Paolo LambertiPaolo Livrea
May 11, 2005·World Journal of Gastroenterology : WJG·Birol OzerSedat Boyacioglu
Dec 8, 2005·The American Journal of Clinical Nutrition·David J StottRudi G J Westendorp
Jan 18, 2006·Seizure : the Journal of the British Epilepsy Association·Ufuk SenerMurat Topbas
Apr 6, 2006·Alcohol·Hidenari Sakuta, Takashi Suzuki
Oct 17, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Marco Righetti
Apr 10, 2009·Investigative Ophthalmology & Visual Science·Preethi S GanapathySylvia B Smith
May 9, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Thomas Müller, Wilfried Kuhn
Sep 23, 2009·Expert Review of Neurotherapeutics·Olaf StangerMichael Linnebank
Jun 19, 2010·International Heart Journal·Dong-Bin KimJae-Hyung Kim
Jul 3, 2010·Journal of the American College of Nutrition·Ligia J DominguezMario Barbagallo
Jan 18, 2011·Toxicology and Applied Pharmacology·Richelle A HemendingerBenjamin Rix Brooks
Mar 31, 2012·Clinical Hemorheology and Microcirculation·Amparo VayáBegoña Laiz

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Citations

Aug 28, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Han-Tao LiRong-Kuo Lyu
Oct 21, 2016·Muscle & Nerve·Jin Jun Luo, Nae J Dun
Dec 17, 2020·Frontiers in Neurology·Xujun ChuYun Yuan
Mar 2, 2021·Frontiers in Systems Neuroscience·Shengming HuangYuejun Tian

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