Clinical manifestations of sickle cell disease in India: misconceptions and reality

Current Opinion in Hematology
Dipty Jain, Dipika Mohanty

Abstract

In the past, milder clinical manifestations of sickle cell disease (SCD) have been described from India. However, recent data from some parts of India suggest that the severity of the disease can be compared to that of African phenotypes. This review therefore describes the varied clinical manifestation of SCD, the success of newborn screening programme, prenatal diagnosis and low dose hydroxyurea therapy in India. The varied clinical manifestations such as anemia, vaso-occlusive crisis, acute chest syndrome, renal involvement, stroke and so on vary from one part of the country to the other and also among different communities of India. Strategies for improving quality of life and controlling of SCD have been suggested. Certain factors other than genetics also play an important role in clinical manifestation of the disorder. The clinical diversity of SCD is described. The natural history of SCD in India is unfolding from newborn screening programme. The use of low-dose hydroxy urea therapy both in adults and children has brought down the incidences of crisis and provides great relief to the patients. The tailor-made programme for India as regards the control and management has been discussed.

References

May 1, 1981·Clinical Pediatrics·M C StevensG R Serjeant
Feb 13, 2001·British Journal of Haematology·G R Serjeant
Feb 23, 1952·British Medical Journal·H LEHMANN, M CUTBUSH
Jun 24, 2008·Bulletin of the World Health Organization·Bernadette Modell, Matthew Darlison
Oct 29, 2008·Blood Cells, Molecules & Diseases·Khushnooma ItaliaRoshan Colah
Jul 8, 2010·Indian Journal of Pharmacology·Harminder SinghPawan Tiwari
May 12, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Banu AygunRussell E Ware
Jun 26, 2012·Indian Pediatrics·Dipty JainRoshan Colah
Mar 21, 2013·Asia-Pacific Journal of Public Health·Dipika MohantyVasantha Muthuswamy
Apr 8, 2016·Indian Journal of Pediatrics·Dipty JainGraham Serjeant
Nov 23, 2016·Mediterranean Journal of Hematology and Infectious Diseases·Prasanta PurohitJogeswar Panigrahi
Jan 23, 2017·Journal of Health, Population, and Nutrition·Gayatri DesaiDhiren Modi
May 26, 2017·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Gnanasambandan RamanathanBhaskar V K S Lakkakula
Jan 1, 2015·The Botulinum Journal·Kelly A JacksonRyan P Fagan

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Citations

Jun 3, 2021·Journal of the Neurological Sciences·Pallab BhattacharyaOfelia Alvarez

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