Clinical Markers and Outcomes of Neonates With Herpes Simplex Virus Deoxyribonucleic Acid Persistence in Cerebrospinal Fluid in Disseminated and Central Nervous System Infection

Journal of the Pediatric Infectious Diseases Society
William R OttoMary Anne Jackson

Abstract

We compared the clinical course of neonates with persistence of herpes simplex virus (HSV) deoxyribonucleic acid (DNA) in the cerebrospinal fluid (CSF) after 21 days of treatment with high-dose acyclovir to that of neonates with clearance of the CSF after 21 days of therapy. Neonates with persistence of HSV DNA had a more severe clinical course with worse neurodevelopmental outcomes.

Citations

Sep 29, 2018·Annual Review of Virology·Claudette L Poole, David W Kimberlin
Dec 12, 2021·Journal of the Pediatric Infectious Diseases Society·Lisa N Akhtar, David W Kimberlin

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