PMID: 8943835Oct 1, 1996Paper

Clinical measures, smoking, radon exposure, and risk of lung cancer in uranium miners

Occupational and Environmental Medicine
M M Finkelstein

Abstract

Exposure to the radioactive daughters of radon is associated with increased risk of lung cancer in mining populations. An investigation of incidence of lung cancer following a clinical survey of Ontario uranium miners was undertaken to explore whether risk associated with radon is modified by factors including smoking, radiographic silicosis, clinical symptoms, the results of lung function testing, and the temporal pattern of radon exposure. Miners were examined in 1974 by a respiratory questionnaire, tests of lung function, and chest radiography. A random selection of 733 (75%) of the original 973 participants was followed up by linkage to the Ontario Mortality and Cancer Registries. Incidence of lung cancer was increased threefold. Risk of lung cancer among miners who had stopped smoking was half that of men who continued to smoke. There was no interaction between smoking and radon exposure. Men with lung function test results consistent with airways obstruction had an increased risk of lung cancer, even after adjustment for cigarette smoking. There was no association between radiographic silicosis and risk of lung cancer. Lung cancer was associated with exposures to radon daughters accumulated in a time window four to 14 yea...Continue Reading

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Citations

Nov 25, 2003·The Science of the Total Environment·Francisco Franco-MarinaLeticia Tavera
Jun 24, 2008·Journal of Toxicology and Environmental Health. Part a·Dirk TaegerThomas Bruning
Jun 27, 2014·Pathology International·Manabu Fukumoto
Feb 23, 2007·American Journal of Industrial Medicine·Olav AxelsonMats Frederickson

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