Clinical Milestones Preceding the Diagnosis of Multiple System Atrophy and Progressive Supranuclear Palsy: A Retrospective Cohort Study

Journal of Movement Disorders
Louise WiblinDavid J Burn

Abstract

Multiple System Atrophy (MSA) and progressive supranuclear palsy (PSP) are rapidly progressive forms of degenerative Parkinsonism. The difficulties of diagnosing MSA and PSP in their early stages may lead to delayed referral to appropriate specialists and distress to patients, as well as delaying symptomatic treatment and participation in clinical trials. This work aimed to describe the symptoms that patients with MSA and PSP developed and plot their emergence relative to final diagnosis using a median onset in months. Forty-seven patients from the United Kingdom with MSA or PSP diagnosed by a movement disorder specialist were interviewed with carers or relatives to establish milestone onset. This was corroborated using clinical notes and letters. In the MSA cohort (n = 23), autonomic symptoms (median 5.5 months before diagnosis) and falls (median 1 month before diagnosis) were the two clinical milestones which occurred before diagnosis. In the PSP cohort (n = 24), falling was the only milestone which occurred before diagnosis (median of 18.5 months). This Study Shows That Psp Patients Experience Falling More Than A Year And A Half An Average Before Receiving A Diagnosis And Although Msa Patients Also Tended To Fall, This Was M...Continue Reading

References

Jan 10, 2008·Research in Nursing & Health·Melody A Hertzog
Apr 4, 2008·Brain : a Journal of Neurology·S S O'SullivanA J Lees
Aug 24, 2013·Parkinsonism & Related Disorders·Claudia dell'AquilaGiancarlo Logroscino
Sep 16, 2015·Brain : a Journal of Neurology·Elizabeth A CoonWolfgang Singer
Jan 23, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Lucia RicciardiAlfonso Fasano
Feb 2, 2016·Journal of Movement Disorders·Helen Ling
Mar 3, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Stella Andrea GlasmacherRomi Anirban Saha
May 4, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Günter U HöglingerUNKNOWN Movement Disorder Society-endorsed PSP Study Group

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Citations

Apr 19, 2019·Internal Medicine·George Umemoto, Hirokazu Furuya
Aug 6, 2020·Journal of Physical Therapy Science·Hironobu UzawaYusuke Nishida
Jan 2, 2021·Journal of the Neurological Sciences·John C MorganTao Xie

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