Clinical, molecular and epidemiological description of a cluster of community-associated methicillin-resistant Staphylococcus aureus isolates from injecting drug users with bacteraemia.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
F J CookeN M Brown

Abstract

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an increasing problem, predominantly in previously healthy individuals including notable risk groups such as the homeless, those who play close-contact sports, military personnel, men who have sex with men (MSM) and injecting drug users (IDUs). Over a 5-month period, four IDUs were admitted to Addenbrooke's Hospital, Cambridge, UK, with MRSA bacteraemia. All four patients presented with complex clinical features, with more than one focus of infection, and were linked epidemiologically. The atypical antibiogram of the MRSA isolates (ciprofloxacin-susceptible) prompted further characterization, both phenotypically (antibiotic resistance typing; phage typing) and genotypically (detection of toxin genes by PCR; pulsed-field gel electrophoresis (PFGE); Staphylococcal chromosome cassette (SCC) mec typing; multi-locus sequence typing (MLST)). All four isolates had similar antibiograms, were Panton-Valentine Leucocidin (PVL) toxin gene-negative, harboured SCCmec type IV and were closely related as shown by phage typing and PFGE. These isolates were representatives of a community-associated clone, ST1-MRSA-IV, known to be circulating in IDUs in the UK since 20...Continue Reading

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Oct 16, 2007·The Journal of Hospital Infection·J A OtterG L French

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Citations

Jun 15, 2012·The New England Journal of Medicine·Claudio U KöserSharon J Peacock
Dec 12, 2012·American Journal of Infection Control·Luke F Chen
May 25, 2012·The Journal of Hospital Infection·J A Otter, G L French
Mar 11, 2011·Journal of Medical Microbiology·Karishma S KaushikA K Praharaj
May 9, 2013·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Courtney R MurphySusan S Huang
Mar 15, 2015·International Journal of Antimicrobial Agents·Matthew J EllingtonSharon J Peacock
May 28, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Alireza Japoni-NejadEhsanollah Ghaznavi-Rad
Jul 4, 2012·American Journal of Infection Control·Steven J SchweonCarmen Acosta
Feb 27, 2021·Frontiers in Microbiology·Nannan Wu, Tongyu Zhu
Mar 26, 2010·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Tatsuo YamamotoDa Shi

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