Clinical molecular imaging in intestinal graft-versus-host disease: mapping of disease activity, prediction, and monitoring of treatment efficiency by positron emission tomography

Blood
Matthias StelljesJoachim Kienast

Abstract

Gastrointestinal graft-versus-host disease (GVHD) is a common and potentially life-threatening complication after allogeneic hematopoietic stem-cell transplantation (HSCT). Noninvasive tests for assessment of GVHD activity are desirable but lacking. In the present study, we were able to visualize intestinal GVHD-associated inflammation in an allogeneic murine transplantation model by (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in vivo. A predominant localization of intestinal GVHD to the colon was verified by histology and fluorescence reflectance imaging of enhanced green fluorescent protein (EGFP)-expressing donor cells. Colonic infiltration by EGFP(+) donor lymphocytes matched increased FDG uptake in PET examinations. These preclinical data were prospectively translated into 30 patients with suspected intestinal GVHD beyond 20 days after transplantation. A total of 14 of 17 patients with a diagnostic histology showed significant FDG uptake of the gut, again predominantly in the colon. No increased FDG uptake was detected in 13 patients without histologic evidence of intestinal GVHD. Our findings indicate that FDG-PET is a sensitive and specific noninvasive imaging technique to assess intestinal GVHD, map ...Continue Reading

References

Nov 17, 2010·The Journal of Experimental Medicine·Jörn C AlbringKenneth M Murphy
Dec 8, 2009·Nuclear Medicine Communications·Vibhudutta AwasthiRobert Epstein
Jun 3, 2009·Clinical Nuclear Medicine·Sonali RaoRaghuveer K Halkar
Feb 9, 2010·Clinical Nuclear Medicine·Erik Mittra, I Ross McDougall
May 21, 2010·The Journal of Clinical Investigation·Evan Nair-GillOwen N Witte
Sep 25, 2012·EJNMMI Research·Barry C GibneySteven J Mentzer
Oct 1, 2013·Bone Marrow Transplantation·C Bodet-MilinMohamad Mohty
Apr 16, 2014·Mediators of Inflammation·Florent Malard, Mohamad Mohty
Nov 26, 2009·Current Opinion in Genetics & Development·Rachel E LaingCaius G Radu
Apr 27, 2012·British Journal of Haematology·Fiona L DignanBritish Society for Blood and Marrow Transplantation
Nov 10, 2015·Bone Marrow Transplantation·L AngenendtWolfgang E Berdel
Feb 4, 2009·Seminars in Nuclear Medicine·Michael J O'DohertyJohn L Klein
Apr 14, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Prakash VaradarajanPhilip L McCarthy
Nov 16, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Evgenios GoussetisStelios Graphakos
Jun 11, 2014·Blood·Shernan G HoltanDaniel J Weisdorf
Jun 2, 2016·American Journal of Clinical Pathology·Marcela SalomaoAntonia Sepulveda
Jan 25, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Henrike J FischerHolger M Reichardt
Mar 30, 2018·The Journal of Clinical Investigation·Israt S AlamSanjiv S Gambhir
Sep 1, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Stefanie PektorMatthias Miederer
Jan 1, 2017·European Journal of Hybrid Imaging·Florian BütherLars Stegger
May 25, 2011·International Journal of Laboratory Hematology·Z YanS Ding
Sep 3, 2020·Technology in Cancer Research & Treatment·Zixuan ZhaoShengming Deng
Nov 2, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniela G SeidlerMartin Götte
Aug 15, 2020·Frontiers in Immunology·Rebecca A Brown, Craig A Byersdorfer

Citations

Mar 7, 1991·The New England Journal of Medicine·J L Ferrara, H J Deeg
Feb 1, 1986·Gastroenterology·G B McDonaldG D Spencer
Jun 1, 1995·American Journal of Clinical Pathology·J A BombíA Cardesa
Nov 30, 2000·The American Journal of Gastroenterology·N IqbalC M Wilcox
Mar 29, 2001·Experimental Hematology·H GokerN J Chao
Jun 1, 2001·Nature Medicine·J W Fabre
Jul 19, 2002·Archives of Internal Medicine·Imad A TabbaraZeina Nahleh
Aug 8, 2002·Pediatric Radiology·Hans-Joachim MentzelWerner A Kaiser
Oct 3, 2002·Annual Review of Medicine·Georgia B VogelsangDebra M Bensen-Kennedy
Dec 19, 2002·Drugs·Hiroyuki TakatsukaEizo Kakishita
Apr 28, 2004·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Paul J MartinR Storb
Mar 5, 2005·Blood·Elizabeth TivolWilliam R Drobyski
Mar 31, 2005·Radiographics : a Review Publication of the Radiological Society of North America, Inc·David L CoyTasneem Lalani
Aug 22, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·C CastillaJ F San Miguel
Oct 6, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Nicole CauchonJohan E van Lier
Oct 20, 2006·Apoptosis : an International Journal on Programmed Cell Death·Revital AloyaIlan Ziv

Related Concepts

Establishment and Maintenance of Localization
Molecular Imaging
Taenia Coli
Histology Procedure
Positron-Emission Tomography
Cell Motility
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
FDG-Positron Emission Tomography
Murine
Whole Body Screening

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.