PMID: 20646650Jul 22, 2010Paper

Clinical multivariate regression analysis of local recurrence following curative surgery for rectal cancer

Zhonghua yi xue za zhi
Wei-min ZhaoHai-jiang Wang

Abstract

To investigate the clinicopathologic factors related to local recurrence following curative surgery for rectal cancer and explore the ways to improve the efficacies. A total of 257 post-operative cases of rectal cancers from January 1995 to December 2002 were recruited. And the relation of each clinicopathologic characteristic and local post-operative recurrence was retrospectively investigated. The clinicopathologic factors and follow-up data were analyzed by uni and multi-factorial regression model by logistic regression. The total local recurrence rate of rectal cancer after radical operation was 18.7%, 75.0% (36/48) within 2 years and 95.8% (45/48) within 3 years, the median time was 14.6 months (range: 2-63). Univariate analysis showed that age, Dukes' stage, lymph node metastasis and level of CEA were significantly associated with the local post-operative recurrence (P<0.05). Multivariate analysis showed that age and lymph node metastasis were closely related with the local post-operative recurrence (P<0.05). Lymph node metastasis and age are very important prognostic factors for the local post-operative recurrence. It is possible to improve the prognosis of rectum cancer by making an early diagnosis and offering a scient...Continue Reading

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