Clinical neurological findings of children with acute lymphoblastic leukaemia at diagnosis and during treatment

European Journal of Pediatrics
Leena K Vainionpää

Abstract

Serial neurological evaluation was performed on 40 consecutive children with acute lymphoblastic leukaemia (ALL) at the time of diagnosis and during treatment. Abnormal neurological signs were found in 23% of the patients, including some without neurological symptoms on admission. Six patients (15%) had abnormal funduscopy findings, papilloedema or preretinal haemorrhages, and 3 of them had increased intracranial pressure measured in connection with a diagnostic lumbar puncture but without blasts in their CSF. The reason for the increased intracranial pressure remained unclear. The development of neurological symptoms caused by peripheral neuropathy during induction therapy was related to the total dose and duration of vincristine therapy. The most severe walking difficulties, patients moving about on all fours for as long as 6 weeks-5 months, occurred in a group who were significantly younger than the other children (P < 0.03). Fine and gross motor disturbances occurred in 18% and 30% of the whole patient group, respectively, after 2-3 years of therapy. Impaired short-term memory was observed in 21% of the patients after 2-3 years of therapy, indicating impaired CNS function. The results indicate that chemotherapy also seems t...Continue Reading

References

Oct 1, 1979·Pediatric Annals·K S Holt
Dec 1, 1978·The Journal of Pediatrics·J C Allen
Sep 1, 1977·Archives of Disease in Childhood·M A GribbinJ M Chessells
Feb 1, 1976·Cancer·S McIntoshH A Pearson
Aug 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R K MulhernJ Ochs
May 1, 1990·Archives of Disease in Childhood·R E AppletonP Rogers
Jan 1, 1986·Pediatric Hematology and Oncology·M P GerrardJ S Lilleyman
Jun 1, 1985·Archives of Disease in Childhood·N H RussellJ Martin
Mar 14, 1970·Lancet·J L NaimanP Philippidis
Feb 1, 1970·Journal of the Neurological Sciences·W G BradleyJ N Walton
Jan 1, 1973·Brain : a Journal of Neurology·E B CaseyY L Millett
Jun 1, 1972·Archives of Disease in Childhood·H E KayE N Thompson
Apr 1, 1973·The Journal of Pediatrics·F L JohnsonR L Chard
Dec 22, 1984·Lancet·J J OchsJ V Simone
Sep 1, 1983·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S B ParyaniM P Link

❮ Previous
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Citations

Jan 15, 1998·Cancer·A H Harila-SaariB M Lanning
Nov 7, 2009·Breast Cancer Research and Treatment·Felice A TagerDawn L Hershman
Nov 1, 2003·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·M Moleski
Jan 27, 2004·Gait & Posture·Victoria GaleaRonald D Barr
May 5, 1999·Critical Reviews in Oncology/hematology·C E GiddingS S de Graaf
Oct 11, 2005·Journal of the International Neuropsychological Society : JINS·Annemieke I BuizerAnjo J P Veerman
Mar 11, 2010·Journal of Pediatric Hematology/oncology·Steven K Baker, David M Lipson
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert E GoldsbyRoger J Packer
Jun 1, 2010·Pakistan Journal of Biological Sciences : PJBS·A A G TantawyA A N A El Aziz
Apr 26, 2000·Pediatric Hematology and Oncology·G LjungmanA Kreuger
Sep 25, 2001·Medical and Pediatric Oncology·H A Reinders-MesselinkW A Kamps
Nov 17, 2009·Journal of the Peripheral Nervous System : JPNS·Sindhu RamchandrenJames G Gurney
Mar 13, 2013·Developmental Neurorehabilitation·Cinzia R De LucaJacqueline Williams
Feb 5, 2011·Seizure : the Journal of the British Epilepsy Association·Hadassa Goldberg-SternAvinoam Shuper
Dec 1, 1996·Medical and Pediatric Oncology·H A Reinders-MesselinkW A Kamps
Nov 11, 2016·Scientific Reports·Einar-Jón EinarssonChristian Moëll
Jul 29, 1998·Medical and Pediatric Oncology·M J WrightR D Barr
Nov 26, 1999·Medical and Pediatric Oncology·H Reinders-MesselinkW Kamps
Jan 31, 2004·Pediatric Blood & Cancer·Victoria G MarcheseBeverly J Lange
Jul 13, 2002·Medical and Pediatric Oncology·Francesca FioreddaIsabella Fiocchi
Jan 30, 2003·Medical and Pediatric Oncology·Victoria Gocha MarcheseBeverly J Lange
Jun 20, 2019·Cancer Chemotherapy and Pharmacology·Marie Lindhard MadsenKaren Dybkær
Oct 1, 2014·Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie·Cheryl L SabarreJill G Zwicker
Sep 26, 2021·Current Opinion in Pediatrics·Kristie N RamosKenneth S Ramos

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