Clinical next-generation sequencing reveals aggressive cancer biology in adolescent and young adult patients

Oncoscience
Vivek SubbiahDavid Hong

Abstract

The aggressive biology of cancers arising in adolescent and young adult (AYA; ages 15-39 years) patients is thought to contribute to poor survival outcomes. We used clinical next-generation sequencing (NGS) results to examine the molecular alterations and diverse biology of cancer in AYA patients referred to the Phase 1 program at UT MD Anderson Cancer Center. Among the 28 patients analyzed (14 female and 14 male), 12 had pediatric-type cancers, six had adult-type cancers, and ten had orphan cancers. Unique, hitherto unreported aberrations were identified in all types of cancers. Aberrations in TP53, NKX2-1, KRAS, CDKN2A, MDM4, MCL1, MYC, BCL2L2, and RB1 were demonstrated across all tumor types. Five patients harbored TP53 aberrations; three patients harbored MYC, MCL1, and CDKN2A aberrations; and two patients harbored NKX2-1, KRAS, MDM4, BCL2L2, and RB1 alterations. Several patients had multiple aberrations; a patient with wild-type gastrointestinal stromal tumor harbored five alterations (MDM4, MCL1, KIT, AKT3, and PDGRFA). This preliminary report of NGS of cancer in AYA patients reveals diverse and unique aberrations. Further molecular profiling and a deeper understanding of the biology of these unique aberrations are warran...Continue Reading

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Citations

May 26, 2017·CA: a Cancer Journal for Clinicians·Carol E DeSantisAhmedin Jemal
Feb 19, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Coline H M van MoorselJan C Grutters

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Methods Mentioned

BETA
exome sequencing

Clinical Trials Mentioned

NCT01833520
NCT01582191

Software Mentioned

FoundationOne
ClinicStation

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