Abstract
Juvenile idiopathic arthritis (JIA), known as Juvenile rheumatoid arthritis, is the most common type of arthritis in children aged under 17. It may cause sequelae due to lack of effective treatment. The goal of this study is to explore the therapeutic effect of umbilical cord mesenchymal stem cells (UC-MSCs) for JIA. Ten JIA patients were treated with UC-MSCs and received second infusion three months later. Some key values such as 28-joint disease activity score (DAS28), TNF-α, IL-6, and regulatory T cells (Tregs) were evaluated. Data were collected at 3 months and 6 months after first treatment. DAS28 score of 10 patients was between 2.6 and 3.2 at three months after infusion. WBC, ESR, and CRP were significantly decreased while Tregs were remarkably increased and IL-6 and TNF-α were declined. Similar changes of above values were found after 6 months. At the same time, the amount of NSAIDS and steroid usage in patients was reduced. However, no significant changes were found comparing the data from 3 and 6 months. These results suggest that UC-MSCs can reduce inflammatory cytokines, improve immune network effects, adjust immune tolerance, and effectively alleviate the symptoms and they might provide a safe and novel approach fo...Continue Reading
References
Apr 4, 1997·Science·D J Prockop
Oct 25, 2003·Blood·Oscar K LeeTain-Hsiung Chen
Oct 6, 2005·JAMA : the Journal of the American Medical Association·Philip J Hashkes, Ronald M Laxer
Oct 6, 2005·JAMA : the Journal of the American Medical Association·Sarah RingoldRichard M Glass
Aug 23, 2006·Cytotherapy·M DominiciEm Horwitz
Aug 1, 2007·Blood·Alma J Nauta, Willem E Fibbe
Aug 1, 2008·Arthritis and Rheumatism·Jon M BurnhamMary B Leonard
Dec 8, 2009·Stem Cells·Husein K Salem, Chris Thiemermann
Feb 23, 2010·Stem Cells and Development·Yan XuLugui Qiu
May 28, 2010·Arthritis and Rheumatism·Lingyun SunSongtao Shi
Jul 12, 2011·Stem Cells and Development·Nina ZippelEdda Tobiasch
Apr 14, 2012·TheScientificWorldJournal·Yu ZhangEdda Tobiasch
Jun 29, 2013·Methods in Molecular Biology·Rony Atoui, Ray C J Chiu
Aug 15, 2013·Stem Cells and Development·Liming WangYongjun Liu
Apr 17, 2014·Stem Cells International·Weian ZhaoMauro Krampera
May 28, 2014·Experimental Dermatology·Krisztian Nemeth
Feb 20, 2015·Cell Transplantation·Andrea Del FattoreMaurizio Muraca
Mar 24, 2015·Bioscience Reports·Imran UllahGyu Jin Rho
Mar 31, 2015·Stem Cells International·Katherine Athayde Teixeira de CarvalhoJuan Carlos Chachques
Apr 7, 2015·Expert Review of Clinical Immunology·Andreas WoernerMichaël Hofer
Apr 11, 2015·BioMed Research International·Isaac Perea-GilSantiago Roura
Apr 15, 2015·Microbiology and Immunology·Shereen ShawkiRabab El Hawary
Apr 23, 2015·International Journal of Molecular Medicine·Ningxia SongJianmin Wang
Citations
May 22, 2016·Clinical Reviews in Allergy & Immunology·Alexandre T J MariaPhilippe Guilpain
Oct 14, 2017·Archivum Immunologiae Et Therapiae Experimentalis·Krzysztof Orczyk, Elzbieta Smolewska
Jul 12, 2017·F1000Research·Susan Canny, Elizabeth Mellins
May 10, 2019·Rheumatology·Joost F SwartNico M Wulffraat
Jul 16, 2020·Medicine·Tao QiMinfei Peng
Oct 16, 2020·Cell Transplantation·Linan LiuWeian Zhao
Jun 12, 2021·Pediatric Rheumatology Online Journal·Stephen C WongDeborah K McCurdy