PMID: 25773819Mar 17, 2015Paper

Clinical observation of three dimensional conformal radiotherapy with tamoxifen in treatment of postoperative malignant glioma

Asian Pacific Journal of Cancer Prevention : APJCP
Shao-Bing ZhouXin-En Huang

Abstract

To evaluate the efficacy and adverse effects of three dimensional conformal radiotherapy (3D-CRT) with tamoxifen in treating patients with postoperative malignant glioma. 60 patients of postoperative malignant glioma were randomly assigned into two groups, 30 patients were treated with 3D-CRT plus tamoxifen (treatment group), and the other 30 patients with 3D-CRT plus temozolomide (control group). All patients were radiated by 6MV X-ray, 2.0 Gy per fraction, once daily, with a total dose (DT) of 56~60 Gy. Tamoxifen was delivered at 60 mg /m2/d, temozolomide was given at 75 mg/m2/d. All patients were treated with concurrent radiotherapy. One, 2, 3 year survival rates of treatment and control group were 63.3%, 30.0%, 23.0% and 70.0%, 33.3%, 26.7%, respectively (χ2=0.01, 0.23, 0.09, P>0.05). The rate of thromboembolism in treatment group was 6.7%. Therapeutic efficacy of two groups was similar, but it was more cost- effective in treatment group, and toxicity did not increase.

References

Mar 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A BroniscerL M Cristófani
Nov 21, 2007·Current Opinion in Pediatrics·Sonia Partap, Paul Graham Fisher
Apr 26, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Abdolazim Sedighi PashakiTayebe Torkaman

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