PMID: 8971943Nov 1, 1996Paper

Clinical outcome after coronary surgery with heparin-coated extracorporeal circuits for cardiopulmonary bypass

Perfusion
C BaufretonD Y Loisance

Abstract

In this prospective randomized trial, we studied whether heparin-coated extracorporeal circuits (ECC), known to reduce complement activation, could improve the clinical outcome of 200 patients undergoing coronary artery surgery. Patients have been divided into two groups (heparin-coated ECC and uncoated ECC groups) which were similar in terms of age, gender, left ventricle function, preoperative aspirin use and consequent intraoperative aprotinin use, number of grafts, duration of aortic cross-clamping and cardiopulmonary bypass. Univariate analysis showed that heparin coating did not reduce significantly postoperative bleeding (640 +/- 311 versus 682 +/- 342 ml with uncoated ECC) nor the need for transfusion (19% of patients versus 25% with uncoated ECC). Adverse events, including all mortality and morbidity noticed during the five first postoperative days, occurred in 20 patients of the uncoated ECC group and in eight patients of the heparin-coated ECC group (p = 0.013). The most frequent complications were supraventricular arrhythmias that occurred in 13 patients of the uncoated ECC group and in four patients of the heparin-coated ECC group (p = 0.02). Multivariate analysis by stepwise logistic regression showed that only he...Continue Reading

References

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Citations

Mar 28, 2009·The Annals of Thoracic Surgery·Marco RanucciSimonetta Brozzi
Feb 21, 2006·Annales Françaises D'anesthèsie Et De Rèanimation·C BaufretonF Pinaud
Jan 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Denis SchmartzJean-Louis Vincent
Jun 4, 1999·The Annals of Thoracic Surgery·P M McCarthyD M Cosgrove
Aug 31, 2002·Scandinavian Cardiovascular Journal : SCJ·S SvenmarkerT Aberg
Jul 14, 2010·Archives of Cardiovascular Diseases·Christophe Baufreton
Jun 25, 1998·Perfusion·C B Mahoney
Oct 14, 2020·International Journal of Phytoremediation·Rogelio Carrillo-González, Ma Del Carmen A González-Chávez

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