Clinical outcome after percutaneous treatment of de novo coronary bifurcation lesions using first or second generation of drug-eluting stents

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Miroslaw FerencFranz-Josef Neumann

Abstract

There is increasing evidence that various types of drug-eluting stents (DES) may differ regarding the long-term safety and efficacy, particularly in complex lesion subsets. In a cohort of consecutive patients undergoing bifurcation stenting, we sought to compare the 1-year efficacy and safety of the first-generation paclitaxel-eluting stents (PES), the first-generation sirolimus-eluting (SES) and the second-generation everolimus- or zotarolimus-eluting stents (EES/ZES). We treated 2197 patients (mean age 67.5 years, 75.4 % male) with provisional T-stenting for de novo coronary bifurcation lesions using PES, SES or EES/ZES. Primary endpoint (MACE) was the composite of death from any cause, myocardial infarction (MI) and target lesion revascularisation (TLR). Side branch stenting was found to be clinically indicated in 793 patients (36.1 %). The cumulative 1-year incidence of MACE was 18.8 % after PES, 13.1 % after PCI with SES and 12.2 % after EES/ZES (p = 0.003), the combined endpoint death and MI occurred in 6.6, 5.6 and 8.3 % (p = 0.253) and death in 4.3, 5.2 and 5.3 % (p = 0.581), respectively. After adjustment for co-variables the type of DES was a significant (p = 0.008) predictor of MACE [HR (95 % confidence interval) PES...Continue Reading

Associated Clinical Trials

References

May 5, 2005·JAMA : the Journal of the American Medical Association·Ioannis IakovouAntonio Colombo
Dec 28, 2006·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Carlo Di MarioGiuseppe M Sangiorgi
Nov 7, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Yves LouvardThierry Lefèvre
Mar 17, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Antoinette de WahaAdnan Kastrati
Feb 7, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Ibrahim AkinChristoph A Nienaber
Apr 5, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Goran StankovicUNKNOWN European Bifurcation Club
May 7, 2013·Journal of the American College of Cardiology·Michael MaengUNKNOWN Nordic-Baltic Percutaneous Coronary Intervention Study Group
Oct 26, 2013·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Charis CostopoulosAntonio Colombo
Jan 29, 2014·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·I AkinM W Bergmann
Feb 14, 2014·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Antonia SchulzFranz X Kleber

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Citations

Oct 23, 2016·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Aurel TomaHeinz Joachim Buettner
Dec 10, 2017·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Stephane FournierUNKNOWN on behalf on the AMIS Plus Investigators
Oct 7, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Athanasios KatsikisPatrick W Serruys
Feb 27, 2017·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Aurel TomaHeinz Joachim Buettner
Jul 28, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Miroslaw FerencThomas G Nührenberg
Aug 14, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Rodrigo ModoloPatrick W Serruys

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