Clinical outcome and hemodynamic changes following HCV eradication with oral antiviral therapy in patients with clinically significant portal hypertension.

Journal of Hepatology
Sabela LensXavier Forns

Abstract

Clinically significant portal hypertension (CSPH), defined as a hepatic venous pressure gradient (HVPG) ≥10 mmHg, persists 24 weeks after sustained virological response (SVR) in up to 78% of patients with HCV-related cirrhosis treated with direct-acting antivirals. These patients remain at risk of decompensation. However, long-term paired clinical and hemodynamic data are not available for this population. We conducted a prospective multicenter study in 226 patients with HCV-related cirrhosis and CSPH who achieved SVR after antiviral therapy. Patients with CSPH 24 weeks after end of treatment (SVR24) were offered another hemodynamic assessment 96 weeks after end of treatment (SVR96). All patients were clinically evaluated. Out of 176 patients with CSPH at SVR24, 117 (66%) underwent an HVPG measurement at SVR96. At SVR96, 55/117 (47%) patients had HVPG <10 mmHg and 53% had CSPH (65% if we assume persistence of CSPH in all 59 non-evaluated patients). The proportion of high-risk patients (HVPG ≥16 mmHg) diminished from 41% to 15%. Liver stiffness decreased markedly after SVR (median decrease 10.5 ± 13 kPa) but did not correlate with HVPG changes (30% of patients with liver stiffness measurement <13.6 kPa still had CSPH). Seventeen...Continue Reading

References

Oct 13, 2006·The American Journal of Gastroenterology·Diego RinconRafael Bañares
Aug 8, 2007·Gastroenterology·Cristina RipollUNKNOWN Portal Hypertension Collaborative Group
Mar 13, 2008·Journal of Hepatology·Laurent CasteraAlfredo Alberti
Mar 24, 2009·Journal of Hepatology·Cristina RipollUNKNOWN Portal Hypertension Collaborative Group
Sep 3, 2009·Nature Reviews. Gastroenterology & Hepatology·Jaime BoschJuan Carlos García-Pagan
Sep 6, 2012·Antiviral Therapy·Thomas ReibergerUNKNOWN Vienna Hepatic Hemodynamic Lab and Vienna HIV & Liver Study Group
Dec 27, 2012·JAMA : the Journal of the American Medical Association·Adriaan J van der MeerHarry L A Janssen
Apr 29, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sabela LensJuan Carlos García-Pagán
Jun 1, 2016·Journal of Hepatology·Mattias MandorferMarkus Peck-Radosavljevic
Aug 27, 2017·Journal of Hepatology·Juan Manuel PascasioMaría-Carlota Londoño
Apr 10, 2018·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
Jun 26, 2018·Journal of Hepatology·Luca Saverio BelliUNKNOWN all the contributing centers (www.eltr.org) and the European Liver and Intestine Transplant Association (ELITA)
Aug 1, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mattias MandorferThomas Reiberger

❮ Previous
Next ❯

Citations

Dec 6, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Bingqiong WangHong You
Feb 6, 2021·Hepatology International·Sonia SeliceanJordi Gracia-Sancho
Feb 15, 2021·Journal of Hepatology·Maria Reig, Giuseppe Cabibbo
Nov 27, 2020·Journal of Hepatology·Lisette A P KrassenburgAdriaan J van der Meer
Apr 12, 2021·Clinics in Liver Disease·Mattias Mandorfer, Benedikt Simbrunner
Apr 12, 2021·Clinics in Liver Disease·Daniel Veldhuijzen van ZantenJuan G Abraldes
Apr 16, 2021·Expert Opinion on Emerging Drugs·Jonathan Andrew FallowfieldAndrew Robertson
May 8, 2021·World Journal of Hepatology·Yu Jun WongTiing Leong Ang
May 25, 2021·Minerva Gastroenterology·Elton DajtiAntonio Colecchia
May 28, 2021·Journal of Hepatology·Rajiv JalanVicente Arroyo
Jun 25, 2021·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.euUNKNOWN Panel members:
Jun 23, 2021·Journal of Hepatology·Gennaro D'AmicoPaolo Angeli
Jul 10, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Jesús Rivera-EstebanElisabetta Bugianesi
Jul 10, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Mattias MandorferJuan C García-Pagán
Aug 21, 2021·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Sheng-Hung ChenCheng-Yuan Peng
May 1, 2021·The American Journal of Gastroenterology·Giulia Tosetti, Massimo Primignani
Sep 15, 2021·Journal of Gastroenterology and Hepatology·Ian LockartMark Danta
Oct 12, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Luis Ibáñez-SamaniegoRita Garcia-Martinez
Sep 30, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Erica LafozJuan Carlos García-Pagán
Jan 7, 2022·Hepatology Communications·Laura-Patricia LlovetMaria-Carlota Londoño

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.