Clinical Outcome and Long-term Remission in JIA

Current Rheumatology Reports
M GlerupMarinka Twilt

Abstract

This review assesses the long-term remission and predictors of clinical outcome in patients with juvenile idiopathic arthritis (JIA). A comprehensive literature search was performed including articles published between January 1, 2004 and February 28, 2017. Studies, with a minimum follow-up of 24 months, were selected independently by two reviewers based on in- and exclusion criteria. The objective outcome was inactive disease/clinical remission as defined by the Wallace criteria at last follow-up. The probability of achieving inactive disease and/or clinical remission is dependent on the JIA subcategories studied in the different articles. Overall, a significant proportion of JIA patients still showed signs of active disease at last follow-up. Some studies include patient populations followed for 15 years or more and these patients were exposed to different treatment protocols at disease presentation than patients diagnosed in the biologic era. Although the severity of the morbidity and associated mortality risk has decreased over time, a significant proportion of the current JIA patients still do not reach an inactive disease status within a 2-year follow-up window. Studying the long-term outcome of patients with JIA remains ...Continue Reading

References

Jul 1, 1997·Arthritis and Rheumatism·E H GianniniA Martini
Aug 5, 2010·The Journal of Rheumatology·Matthew L StollMarilynn Punaro
Sep 3, 2010·The Journal of Rheumatology·Ilaria PagniniGabriele Simonini
Feb 3, 2011·The Journal of Rheumatology·Michelle BatthishRayfel Schneider
May 12, 2011·Arthritis and Rheumatism·Ellen NordalUNKNOWN Nordic Study Group of Pediatric Rheumatology
May 30, 2012·Scandinavian Journal of Rheumatology·L BertilssonH Forsblad-d'Elia
Oct 24, 2012·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Hu-Yuan TsaiBor-Luen Chiang
Mar 19, 2013·Pediatric Rheumatology Online Journal·Yonatan Butbul AvielEarl Silverman
Mar 22, 2013·Clinical Rheumatology·Hui HuangYayuan Zhang
Apr 3, 2013·The Journal of Rheumatology·Lillemor BerntsonUNKNOWN Nordic Study Group of Paediatric Rheumatology
May 21, 2014·Annals of the Rheumatic Diseases·Jaime GuzmanUNKNOWN ReACCh-Out investigators
Sep 3, 2014·The Journal of Rheumatology·Carol A WallaceAudrey Hendrickson
May 20, 2015·Annals of the Rheumatic Diseases·Jaime GuzmanUNKNOWN ReACCh-Out investigators
Jul 10, 2016·Autoimmunity Reviews·Rolando Cimaz
Feb 2, 2017·Scandinavian Journal of Rheumatology·M Alberdi-SaugstrupUNKNOWN Nordic Study Group of Pediatric Rheumatology (NoSPeR)
Feb 23, 2017·Pediatric Rheumatology Online Journal·Maria EkelundUNKNOWN Nordic Study Group of Pediatric Rheumatology (NoSPeR)
Feb 24, 2017·Indian Journal of Pediatrics·Mansi DewoolkarRaju P Khubchandani

❮ Previous
Next ❯

Citations

Jun 4, 2019·The Journal of Rheumatology·Stephanie J W Shoop-Worrall, Kimme L Hyrich
Feb 15, 2019·Arthritis Care & Research·Mia GlerupUNKNOWN Nordic Study Group of Pediatric Rheumatology
Oct 30, 2019·Arthritis Research & Therapy·Elisabet BertholdRobin Kahn
Jan 5, 2021·Expert Review of Clinical Immunology·Rodrigo Joel de OliveiraSimone Appenzeller
Jul 25, 2019·The Lancet Child & Adolescent Health·Stephanie J W Shoop-WorrallLucy R Wedderburn
Sep 5, 2020·Arthritis Care & Research·Sulaiman M Al-MayoufUNKNOWN Pediatric Arab Rheumatology Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.